Clinical outcome of native valve infective endocarditis in Khon Kaen: 1990-1999.

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dc.contributor.authorPachirat, Orathaien_US
dc.contributor.authorKlungboonkrong, Viraten_US
dc.contributor.authorTantisirin, Cherdchaien_US
dc.contributor.authorTaweesangsuksakul, Prawiten_US
dc.contributor.authorTasanavivat, Pyataten_US
dc.contributor.authorChetchotisakd, Ploenchanen_US
dc.contributor.authorLimwattananon, Suponen_US
dc.date.accessioned2009-05-27T21:59:08Z
dc.date.available2009-05-27T21:59:08Z
dc.date.issued2002-02-26en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To compare the survival of infective endocarditis (IE) patients following different treatment strategies and to determine the predictors of patient survival. BACKGROUND: IE is a life-threatening infectious disease that is often difficult to manage. Studies on long-term outcome are limited. METHOD: Data on 152 patients with IE from 1990 to 1999 were collected from two hospitals. The main outcome is death after definite diagnosis of native valve IE. RESULTS: The overall case fatality rate was 38 per 100 patient-years. Survival curves showed better survival for patients treated with surgery compared with patients treated medically (p <0.0001). Survival rate at year 1 was 72 per cent for surgically treated patients and 33 per cent for medically treated patients. Five-year survival rates were 66 per cent and 27 per cent in the two groups, respectively. Based on Cox proportional hazards regression analysis, surgery to be an independent predictor of survival (relative risk [RR] = 0.23; 95% confidence interval [CI] 0.14 to 0.39, p < 0.0001), while the presence of congestive heart failure (RR = 2.55; 95% CI 1.61 to 4.02, p < 0.0001), and being male (RR = 1.76; 95% CI 1.04 to 2.82, p <0.05) were independent predictors of mortality. CONCLUSION: Patients with native valve endocarditis have a high long-term mortality rate. The most common types of cardiac death are post-operative and sudden death. Surgical treatment was the preventive factor of mortality.en_US
dc.description.affiliationDivision of Cardiovascular Disease and Internal Medicine, Khon Kaen University, Thailand.en_US
dc.identifier.citationPachirat O, Klungboonkrong V, Tantisirin C, Taweesangsuksakul P, Tasanavivat P, Chetchotisakd P, Limwattananon S. Clinical outcome of native valve infective endocarditis in Khon Kaen: 1990-1999. Journal of the Medical Association of Thailand. 2002 Feb; 85(2): 139-46en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45746
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshEndocarditis, Bacterial --mortalityen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleClinical outcome of native valve infective endocarditis in Khon Kaen: 1990-1999.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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