Renal dysfunction as an independent predictor of total mortality after acute coronary syndrome: the Thai ACS Registry.

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dc.contributor.authorSooklim, Khorawiten_US
dc.contributor.authorSrimahachota, Suphoten_US
dc.contributor.authorBoonyaratavej, Smonpornen_US
dc.contributor.authorKanjanavanit, Rungsriten_US
dc.contributor.authorSiriviwattanakul, Napaen_US
dc.contributor.authorPiamsomboon, Chumpolen_US
dc.contributor.authorRatanaprakarn, Rangsonen_US
dc.contributor.author,en_US
dc.date.accessioned2009-05-27T21:22:00Z
dc.date.available2009-05-27T21:22:00Z
dc.date.issued2007-10-25en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: Renal insufficiency in the acute coronary syndrome (ACS) is associated with poor cardiac outcome. In Asian populations, there are no data available for these associations. MATERIAL AND METHOD: Data was from the Thai ACS registry, only a new case of ACS. Clinical characteristics, treatment strategies, in-hospital mortality and 1-year mortality were compared for patients with normal or mild renal dysfunction (estimated glomerular filtration rate [eGFR]> 60 ml/minute/1.73 m2, n = 809 [44.5%]), moderate renal dysfunction (eGFR 30-60 ml/minute/1.73 m2, n = 706 [38.9%]), and severe renal dysfunction (eGFR < 30 ml/minute/1.73 m2, n = 301 [16.6%]). RESULTS: Of the 1,816patients with mean follow-up 10.8 months, the mean age was 65 years, and 59.2 percent of the groups were male. Patients with severe renal dysfunction were significantly older, less likely to be male (45.2%, p < 0.001) and had a greater prevalence of diabetes (63.1%, p < 0.001) and hypertension (85.4%, p < 0.001). In-hospital and 1-year mortality were 13.5% and 22.5% respectively. According to discharge diagnosis, unadjusted hazard ratios for overall in-hospital mortality was statistically significant only in ST elevation MI subgroup, hazard ratio was 2.73 (95% CI, 1.72 to 4.34) and 6.27 (95% CI, 3.78 to 10.4) for moderate and severe renal dysfunction group, respectively. The risk of death for all types of ACS at 1-year follow up increased when eGFR decreased below 60 ml/minute/1.73 m2, the adjusted hazard ratio was 1.66 (95% CI,1.22 to 2.23) and 1.91 (95% CI, 1.34 to 2.72) for moderate and severe renal dysfunction group, respectively. CONCLUSION: From Thai ACS registry, renal dysfunction at presentation is an independent predictor for the overall 1-year mortality and appeared to associate with an increase in hospital mortality in the subsets with STEMIen_US
dc.description.affiliationDivision of Cardiology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.en_US
dc.identifier.citationSooklim K, Srimahachota S, Boonyaratavej S, Kanjanavanit R, Siriviwattanakul N, Piamsomboon C, Ratanaprakarn R, . Renal dysfunction as an independent predictor of total mortality after acute coronary syndrome: the Thai ACS Registry. Journal of the Medical Association of Thailand. 2007 Oct; 90 Suppl 1(): 32-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44664
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAcute Coronary Syndrome --complicationsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshCreatinine --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolytic Agents --therapeutic useen_US
dc.subject.meshGlomerular Filtration Rateen_US
dc.subject.meshHospital Mortality --trendsen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Diseases --etiologyen_US
dc.subject.meshLength of Stayen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRegistriesen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleRenal dysfunction as an independent predictor of total mortality after acute coronary syndrome: the Thai ACS Registry.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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