Status of lipid peroxidation and plasma iron level in bronchial asthmatic patients.

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dc.contributor.authorNarula, M Ken_US
dc.contributor.authorAhuja, G Ken_US
dc.contributor.authorWhig, Jen_US
dc.contributor.authorNarang, A P Sen_US
dc.contributor.authorSoni, R Ken_US
dc.date.accessioned2007-07-18en_US
dc.date.accessioned2009-06-01T08:03:43Z
dc.date.available2007-07-18en_US
dc.date.available2009-06-01T08:03:43Z
dc.date.issued2007-07-18en_US
dc.description.abstractLow antioxidant levels and oxidative stress due to airway inflammation may be determinant of asthma severity. The study was conducted to find the extent of lipid peroxidation and change in the levels of plasma iron in asthmatic patients with severity of disease. Study included 155 asthmatic and 156 healthy volunteers of the age groups 18-45 of either sex. Asthmatic patients were grouped into mild, moderate and severe groups on the basis of Forced Expiratory Volume in first second percent (FEV1%). Level of plasma malondialdhyde (MDA) was used as index of lipid peroxidation. A significant increase (P<0.01) in plasma MDA and plasma iron levels was found in asthmatic subjects as compared to controls. There was maximum increase in plasma MDA and iron levels in moderate asthmatic group. A positive correlation between plasma MDA and iron (r = +0.3) has been found in asthmatic patients. An increased plasma iron levels in asthmatics may contribute to aggravate lipid peroxidation.en_US
dc.description.affiliationDepartment of Physiology, Dayanand Medical College and Hospital, Ludhiana. narula.manjeetkaur@yahoo.co.inen_US
dc.identifier.citationNarula MK, Ahuja GK, Whig J, Narang AP, Soni RK. Status of lipid peroxidation and plasma iron level in bronchial asthmatic patients. Indian Journal of Physiology and Pharmacology. 2007 Jul-Sep; 51(3): 289-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108629
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAsthma --blooden_US
dc.subject.meshBronchospirometry --methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volumeen_US
dc.subject.meshHumansen_US
dc.subject.meshIron --blooden_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehyde --blooden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.titleStatus of lipid peroxidation and plasma iron level in bronchial asthmatic patients.en_US
dc.typeJournal Articleen_US
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