Drug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen.

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dc.contributor.authorGreen, E
dc.contributor.authorObi, C.L
dc.contributor.authorNchabeleng, M
dc.contributor.authorVilliers, B.E. de
dc.contributor.authorSein, P.P
dc.contributor.authorLetsoalo, T
dc.contributor.authorHoosen, A.A
dc.contributor.authorBessong, P.O
dc.contributor.authorNdip, R.N
dc.date.accessioned2016-02-18T04:43:39Z
dc.date.available2016-02-18T04:43:39Z
dc.date.issued2010-02
dc.description.abstractMultidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. The prevalence of drug resistance in Mycobacterium tuberculosis (MTB) isolates (n=692) from Mpumalanga province was assessed. In total, 692 (64%) MTB strains from cases with pulmonary TB were tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960 instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs. Resistance to one drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. The prevalence of MDR-TB ranged from 6.7% for three drugs to 34% for four drugs, with significant predictors being patients’ age-groups of 25-54 years (p=0.0012) and >55 years (p=0.007). The result showed a high level (58.4%) of MDR-TB from cases in Mpumalanga province. To achieve a higher cure rate in this province, drug-susceptibility tests must be done for every case.en_US
dc.identifier.citationGreen E, Obi C.L, Nchabeleng M, Villiers B.E. de, Sein P.P, Letsoalo T, Hoosen A.A, Bessong P.O, Ndip R.N. Drug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen. Journal of Health, Population and Nutrition. 2010 Feb; 28(1):7-13.en_US
dc.identifier.issn1606-0997
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/173348
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975841/?report=classicen_US
dc.subjectDrug resistanceen_US
dc.subjectMicrobialen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectRisk factorsen_US
dc.subjectTuberculosisen_US
dc.subjectSouth Africaen_US
dc.titleDrug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen.en_US
dc.typeArticleen_US
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