Acetaminophen (paracetamol) pharmacokinetics in contraceptive pill-using Myanmar women

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dc.contributor.authorCho Cho Myinten_US
dc.contributor.authorAung Naingen_US
dc.contributor.authorTha, Saw Johnsonen_US
dc.contributor.authorKhin Kyi Kyien_US
dc.date.accessioned2009-06-30T08:46:41Z
dc.date.available2009-06-30T08:46:41Z
dc.date.created1989-12-01en_US
dc.date.issued1989-12-01en_US
dc.description.abstractAcetaminophen (paracetamol) pharmacokinetic study was made on a total of 16 healthy adult Myanmar women of reproductive age, half of whom were pretreated chronically for 6 month with an oral contraceptive steroid (OCS), namely, Combination 5. Single oral dose (930 mg) of acetaminophen showed similar extent of maximum plasma acetaminophen concentration in either group. However, the OCS causes significant effect (p<0.05) on plasma acetaminophen resulting in shortening of half-life by 21.6 per cent and augmentation of clearance by 5.9 per cent. The OCS affected predominantly the sulphate conjugation of acetaminophen. In regimen requiring repeated dosing, acetaminophen should be administered more frequently in the pill-users.en_US
dc.identifier.citationCho Cho Myint, Aung Naing, Tha, Saw Johnson, Khin Kyi Kyi. Acetaminophen (paracetamol) pharmacokinetics in contraceptive pill-using Myanmar women. Myanmar Health Sciences Research Journal. 1989; 1(3): 153-156en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/126910
dc.subject.meshAcetaminophenen_US
dc.subject.meshPharmacokineticsen_US
dc.subject.meshContraceptives, Oralen_US
dc.subject.meshMyanmaren_US
dc.titleAcetaminophen (paracetamol) pharmacokinetics in contraceptive pill-using Myanmar womenen_US
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