Treatment of chronic anal fissure with topical glyceryl trinitrate: a double-blind, placebo-controlled trial.

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dc.contributor.authorChaudhuri, Sen_US
dc.contributor.authorPal, A Ken_US
dc.contributor.authorAcharya, Aen_US
dc.contributor.authorDey, Aen_US
dc.contributor.authorChowdhury, Aen_US
dc.contributor.authorSantra, Aen_US
dc.contributor.authorDhali, G Ken_US
dc.contributor.authorMaity, S Gen_US
dc.contributor.authorBanerjee, P Ken_US
dc.date.accessioned2001-05-13en_US
dc.date.accessioned2009-05-29T01:58:02Z
dc.date.available2001-05-13en_US
dc.date.available2009-05-29T01:58:02Z
dc.date.issued2001-05-13en_US
dc.description.abstractBACKGROUND: Topical glyceryl trinitrate (GTN) may produce healing of anal fissure by decreasing the high resting anal sphincter pressure in these patients. The present study assessed the efficacy of GTN in chronic anal fissure in a double-blind placebo-controlled trial. METHOD: Patients with chronic anal fissure (for more than 8 weeks) underwent measurement of maximum anal resting pressure (MARP) before and 12 minutes after application of either 0.2% GTN or placebo ointment in a randomized manner. They then received twice-daily local application of their respective ointment for 6 weeks. Symptoms and healing of fissure were assessed; patients were evaluated at 3 months for evidence of relapse. RESULTS: 19 adult patients (12 men) were studied; 10 received GTN and 9 placebo. Mean (SD) MARP decreased from 131.0 (32.3) cm H2O to 93.5 (28.4) cm H2O (p<0.05) with GTN and from 150.5 (36.9) cm H2O to 142.8 (35.0) cm H2O (p=ns) with placebo. Fissure healed in 7 of 10 patients treated with GTN and 2 of 9 patients treated with placebo (p<0.05). There was no relapse of fissure in either group. CONCLUSION: Local application of GTN was effective in healing chronic anal fissure.en_US
dc.description.affiliationDepartment of Gastroenterology, Institute of Post-Graduate Medical Education and Research, Kolkata. schaudhuri@apexmail.comen_US
dc.identifier.citationChaudhuri S, Pal AK, Acharya A, Dey A, Chowdhury A, Santra A, Dhali GK, Maity SG, Banerjee PK. Treatment of chronic anal fissure with topical glyceryl trinitrate: a double-blind, placebo-controlled trial. Indian Journal of Gastroenterology. 2001 May-Jun; 20(3): 101-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63573
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdministration, Topicalen_US
dc.subject.meshAdulten_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshFissure in Ano --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshManometryen_US
dc.subject.meshNitroglycerin --administration & dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVasodilator Agents --administration & dosageen_US
dc.titleTreatment of chronic anal fissure with topical glyceryl trinitrate: a double-blind, placebo-controlled trial.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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