Comparison of wide-field swept source optical coherence tomography angiography and fundus autofluorescence in tubercular serpiginous-like choroiditis

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dc.contributor.authorBrar, Men_US
dc.contributor.authorSharma, Men_US
dc.contributor.authorGrewal, S, Pen_US
dc.contributor.authorGrewal, DSen_US
dc.date.accessioned2020-04-10T02:05:55Z
dc.date.available2020-04-10T02:05:55Z
dc.date.issued2020-01
dc.description.abstractPurpose: To evaluate the potential clinical utility of wide-field swept source optical coherence tomography angiography (SS-OCTA) using a prototype device compared to a wide-field fundus autofluorescence (FAF) for analysis of the disease activity in eyes with tubercular serpiginous-like choroiditis (TBSLC). Methods: Using a prototype SS-OCTA device (PLEX Elite, Carl Zeiss Meditec, Dublin, CA), 17 eyes of 12 consecutive patients with TBSLC were imaged and multiple 12 mm � 12 mm OCTA scans were captured, which were montaged to create wide-field montage OCTA images scans. A wide- FAF (Eidon, CenterVue, Padova, Italy) was performed in the same sitting. Two masked graders independently analyzed OCTA and FAF images for the presence of choroidal lesions, recorded the number of lesions identifiable, and provided a subjective grading for the activity of individual lesion, which were then compared. Results: The total number of lesions identified on FAF were 282 (posterior pole lesions, n = 129 and peripheral lesions n = 153) and on wide-field SS-OCTA were 230 (posterior pole lesions, n = 108 and peripheral lesions n = 122). Active choroidal lesions were comparable on the two machines (n = 28 on FAF and n = 28 on SS-OCTA, respectively); whereas numerous healed lesions were identified on FAF (n = 219) as compared to SS-OCTA (n = 170). There was good correlation among the devices for healed lesions (Pearson correlation, r = 0.82) and active lesions (r = 0.88). Conclusion: There was good correlation between FAF and wide-field SS-OCTA for detection of disease activity in TBSLC; however, FAF depicted greater number of healed lesions compared to wide-field SS-OCTA.en_US
dc.identifier.affiliationsDepartment of Retina, Grewal Eye Institute, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Retina, Grewal Eye Institute, Chandigarh, India; Department of Ophthalmology, Duke University, Durham, North Carolina, USAen_US
dc.identifier.citationBrar M, Sharma M, Grewal S P, Grewal DS. Comparison of wide-field swept source optical coherence tomography angiography and fundus autofluorescence in tubercular serpiginous-like choroiditis. Indian Journal of Ophthalmology. 2020 Jan; 68(1): 106-111en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/197718
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume68en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_78_19en_US
dc.subjectFundus autofluorescenceen_US
dc.subjecttubercular choroiditisen_US
dc.subjectwide-field swept source optical coherence tomography angiographyen_US
dc.titleComparison of wide-field swept source optical coherence tomography angiography and fundus autofluorescence in tubercular serpiginous-like choroiditisen_US
dc.typeJournal Articleen_US
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