In vitro study on the efficacy of zinc oxide and titanium dioxide nanoparticles against metallo beta-lactamase and biofilm producing Pseudomonas aeruginosa.
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Date
2014-07
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Abstract
Pseudomonas aeruginosa contributes to a multitude of infections exhibiting intrinsic resistance to numerous
antibiotics. Metallo beta-lactamase and biofilm production is the most worrisome resistant mechanisms observed
in P. aeruginosa. Emergence of antimicrobial resistance by pathogenic bacteria is a major health problem in
recent years. Zinc oxide and titanium dioxide nanoparticles comprises of well-known inhibitory and bactericidal
effects. The present study is designed to determine the efficacy of zinc oxide and titanium dioxide nanoparticles
against metallo beta-lactamase and biofilm producing P. aeruginosa. A total of 51 non-repetitive P. aeruginosa
isolates were obtained from Bioline laboratory, Coimbatore. Biofilm and metallo beta-lactamase production was
tested by combined disc test and tissue culture plate method. Commercially available zinc and titanium dioxide
nanoparticles were obtained and tested against two metallo beta-lactamase and biofilm producing isolates. Both
the nanoparticles showed appreciable activity at all tested concentrations. Thus, it is concluded that ZnO and
TiO2 nanoparticles may serve as a promising antibacterial agents in coming years.
Description
Keywords
Pseudomonas aeruginosa, Biofilms, Metallo betalactamase, Zinc oxide nanoparticles, Titanium dioxide nanoparticles, Antimicrobial activity
Citation
Vincent Mary Grace, John Neetu Peedikayil, Narayanan P M, Vani V C, Murugan Sevanan. In vitro study on the efficacy of zinc oxide and titanium dioxide nanoparticles against metallo beta-lactamase and biofilm producing Pseudomonas aeruginosa. Journal of Applied Pharmaceutical Science. 2014 July; 4(7): 41-46.