Effect of levamisole as an immunomodulating agent in trophoblastic lesions.

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dc.contributor.authorKhanna, Aen_US
dc.contributor.authorOjha, K Nen_US
dc.contributor.authorGupta, R Men_US
dc.date.accessioned1993-01-01en_US
dc.date.accessioned2009-05-29T10:43:35Z
dc.date.available1993-01-01en_US
dc.date.available2009-05-29T10:43:35Z
dc.date.issued1993-01-01en_US
dc.description.abstractBoth cell mediated immunity and humoral immunity was assessed in 16 patients of hydatidiform mole and 6 patients of choriocarcinoma. Fifty percent patients of choriocarcinoma and 11 patients of vesicular mole were given levamisole (LVM) trial and were followed for 2 months. Absolute lymphocyte count (ALC) was significantly increased in vesicular mole after levamisole treatment but in choriocarcinoma no effect was obtained. Marked improvement of T cell rosette count was also seen in LVM treated patient of both vesicular mole (p < 0.001) and choriocarcinoma. Cutaneous DTH response to 2:4 DNCB in vesicular mole was also increased after LVM. Before treatment only 31.25% patients had strong cutaneous response but after treatment 53.35% patients had strong response, while cases of choriocarcinoma were unaffected. LVM also raised all the serum immunoglobulins (IgG, IgM, IgA) in both vesicular mole and choriocarcinoma. Hence, levamisole therapy was found to have a beneficial effect on both cellular and humoral immunity in the lesions of trophoblasts.en_US
dc.description.affiliationDepartment of Pathology (Immunopathology), Banaras Hindu University, Varanasi.en_US
dc.identifier.citationKhanna A, Ojha KN, Gupta RM. Effect of levamisole as an immunomodulating agent in trophoblastic lesions. Indian Journal of Pathology & Microbiology. 1993 Jan; 36(1): 32-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/72746
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdjuvants, Immunologic --therapeutic useen_US
dc.subject.meshAntibody Formation --drug effectsen_US
dc.subject.meshChoriocarcinoma --immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydatidiform Mole --immunologyen_US
dc.subject.meshImmune Tolerance --drug effectsen_US
dc.subject.meshImmunity, Cellular --drug effectsen_US
dc.subject.meshImmunoglobulins --blooden_US
dc.subject.meshLevamisole --pharmacologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRosette Formationen_US
dc.subject.meshUterine Neoplasms --immunologyen_US
dc.titleEffect of levamisole as an immunomodulating agent in trophoblastic lesions.en_US
dc.typeJournal Articleen_US
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