Determination of ventilatory minute volumes for normocapnic ventilation under anaesthesia in healthy adults.

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dc.contributor.authorPuri, G Den_US
dc.contributor.authorSingh, Hen_US
dc.contributor.authorKaushik, Sen_US
dc.contributor.authorJindal, S Ken_US
dc.date.accessioned1999-01-18en_US
dc.date.accessioned2009-06-03T06:55:44Z
dc.date.available1999-01-18en_US
dc.date.available2009-06-03T06:55:44Z
dc.date.issued1999-01-18en_US
dc.description.abstractBACKGROUND: Mechanical ventilation under anaesthesia needs to be controlled to maintain normal oxygen and carbon dioxide tensions in the blood and to economize on fresh gas flows. Various ventilation nomograms such as Radford's nomogram and Nunn's CO2 predictor are based on data from studies, some of which do not mimic the conditions which prevail under anaesthesia. We, therefore, planned a study to formulate nomograms for normocapnic ventilation for anaesthetized adult subjects. METHODS: Two hundred and fifty-three patients with normal pulmonary function tests, scheduled for elective non-thoracic surgery were studied. Subjects were ventilated with a Siemens Servo 900 B ventilator using CO2 analyser 930 (Siemens-Elema Sweden) to adjust the minute volume sufficient to maintain end-tidal carbon dioxide fraction (FE,CO2) at around 5.5 normocapnia (PaCO2 5.06-5.6 kPa). This was confirmed with arterial blood gas analysis. RESULTS: The mean (SD) ventilation required for male patients was 6.123 (0.91) L [105 (13.1) ml/kg]. This was significantly higher than the requirement for female patients [5.262 (0.82) L; 98.7 (13.3) ml/kg]. The minute volume requirements showed a significant correlation with weight (W), height (H), body surface area, body mass index and other combinations of weight and height such as W x H, W/H, W2, W3 and H/W1/3. Nomograms were constructed for different weights and heights of males and females using multiple regression analysis. These minute volumes were found to be significantly higher than those calculated according to Radford's nomogram as well as Nunn's CO2 predictor and significantly lower than the Adelaide ventilation guide. CONCLUSION: The differences obtained in our nomograms are probably because the earlier ones were based on minute carbon dioxide production and physiological dead space data obtained from widely differing studies, some of which did not resemble conditions prevailing under anaesthesia. None of these used strict inclusion criteria such as pulmonary function tests. These may also be due to a difference in body structure between the subjects studied. Therefore, minute volume requirements calculated based on available western nomograms should not be applied to Indian subjects for normocapnic ventilation under anaesthesia.en_US
dc.description.affiliationPostgraduate Institute of Medical Education and Research, Chandigarh, India.en_US
dc.identifier.citationPuri GD, Singh H, Kaushik S, Jindal SK. Determination of ventilatory minute volumes for normocapnic ventilation under anaesthesia in healthy adults. National Medical Journal of India. 1999 Jan-Feb; 12(1): 6-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119372
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnesthesia, Generalen_US
dc.subject.meshCarbon Dioxide --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLung Volume Measurementsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulmonary Ventilationen_US
dc.subject.meshRespiration, Artificialen_US
dc.titleDetermination of ventilatory minute volumes for normocapnic ventilation under anaesthesia in healthy adults.en_US
dc.typeJournal Articleen_US
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