A study of acute transfusion reactions at a tertiary care center: a retrospective analysis

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dc.contributor.authorDey, Damayanti R.en_US
dc.contributor.authorDhote, Shweta W.en_US
dc.contributor.authorLad, Subhangi Y.en_US
dc.contributor.authorGupta, Sonal S.en_US
dc.date.accessioned2025-05-12T11:41:43Z
dc.date.available2025-05-12T11:41:43Z
dc.date.issued2024-12
dc.description.abstractBackground: Blood transfusion refers to the therapeutic use of blood products, and while often lifesaving, it carries a variety of potential complications. Ensuring access to safe and sufficient blood is a critical component of healthcare, leading to the development of hemovigilance. Hemovigilance is essential for improving patient safety by learning from errors and implementing system-wide changes to prevent their recurrence. A comprehensive assessment of adverse events is the primary goal of hemovigilance. Aim: To assess the frequency and types of acute transfusion reactions (ATRs). Objectives: (1) To examine the types of ATRs related to the specific blood components transfused. (2) To analyze ATRs based on different clinical parameters. Materials and Methods: A retrospective analysis was conducted over 3 years, evaluating all transfusion reactions reported to the Department of Immunohematology and Blood Transfusion at Mahatma Gandhi Mission College and Hospital, Navi Mumbai. Reactions were assessed according to the institution’s established protocol. Statistical analysis was performed using IBM Statistical Package for the Social Sciences version 20, with significance at P < 0.05. Results: During the study period, 22,188 blood component units were issued, of which 38 (0.174%) resulted in an ATR. Febrile non-hemolytic transfusion reactions (FNHTR) accounted for 31 cases (81.58%), allergic transfusion reactions for six cases (15.79%), and one case (2.63%) involved an immunologic hemolytic transfusion reaction caused by alloantibodies. Among the reported ATRs, 37 (97.36%) were associated with packed red cells (PRC), while 1 (2.64%) occurred with fresh frozen plasma (FFP). Conclusion: FNHTR was the most common ATR, followed by allergic reactions. These findings highlight the importance of continuous monitoring and strict adherence to standard protocols in blood transfusion practices to enhance patient safety.en_US
dc.identifier.affiliationsDepartment of Immunohematology and Blood Transfusion, MGM Medical College and Hospital, MGM Institute of Health Sciences (Deemed to be University), Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Immunohematology and Blood Transfusion, MGM Medical College and Hospital, MGM Institute of Health Sciences (Deemed to be University), Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Immunohematology and Blood Transfusion, MGM Medical College and Hospital, MGM Institute of Health Sciences (Deemed to be University), Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Immunohematology and Blood Transfusion, MGM Medical College and Hospital, MGM Institute of Health Sciences (Deemed to be University), Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationDey Damayanti R., Dhote Shweta W., Lad Subhangi Y., Gupta Sonal S.. A study of acute transfusion reactions at a tertiary care center: a retrospective analysis. MGM Journal of Medical Sciences. 2024 Dec; 11(4): 610-615en_US
dc.identifier.issn2347-7946
dc.identifier.issn2347-7962
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247733
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.4103/mgmj.mgmj_131_24en_US
dc.subjectAcute transfusion reactionsen_US
dc.subjectblood componentsen_US
dc.subjectfebrile non-hemolytic transfusion reactionsen_US
dc.subjecthemovigilanceen_US
dc.titleA study of acute transfusion reactions at a tertiary care center: a retrospective analysisen_US
dc.typeJournal Articleen_US
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