Host-pathogen interactions during apoptosis.

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dc.contributor.authorHasnain, Seyed Een_US
dc.contributor.authorBegum, Rasheedaen_US
dc.contributor.authorRamaiah, K V Aen_US
dc.contributor.authorSahdev, Sudhiren_US
dc.contributor.authorShajil, E Men_US
dc.contributor.authorTaneja, Tarvinder Ken_US
dc.contributor.authorMohan, Manjarien_US
dc.contributor.authorAthar, Men_US
dc.contributor.authorSah, Nand Ken_US
dc.contributor.authorKrishnaveni, Men_US
dc.date.accessioned2003-04-08en_US
dc.date.accessioned2009-06-01T14:10:13Z
dc.date.available2003-04-08en_US
dc.date.available2009-06-01T14:10:13Z
dc.date.issued2003-04-08en_US
dc.description72 references.en_US
dc.description.abstractHost pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.en_US
dc.description.affiliationLaboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India. director@www.cdfd.org.inen_US
dc.identifier.citationHasnain SE, Begum R, Ramaiah KV, Sahdev S, Shajil EM, Taneja TK, Mohan M, Athar M, Sah NK, Krishnaveni M. Host-pathogen interactions during apoptosis. Journal of Biosciences. 2003 Apr; 28(3): 349-58en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110637
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis --physiologyen_US
dc.subject.meshBaculoviridae --physiologyen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshProtein Biosynthesisen_US
dc.subject.meshReactive Oxygen Species --metabolismen_US
dc.subject.meshSignal Transduction --physiologyen_US
dc.subject.meshVirus Diseases --metabolismen_US
dc.subject.meshVirus Physiological Phenomenaen_US
dc.titleHost-pathogen interactions during apoptosis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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