Influence of HLA-DR2 phenotype on humoral immunity & lymphocyte response to Mycobacterium tuberculosis culture filtrate antigens in pulmonary tuberculosis.

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dc.contributor.authorSelvaraj, Pen_US
dc.contributor.authorUma, Hen_US
dc.contributor.authorReetha, A Men_US
dc.contributor.authorXavier, Ten_US
dc.contributor.authorPrabhakar, Ren_US
dc.contributor.authorNarayanan, P Ren_US
dc.date.accessioned1998-05-22en_US
dc.date.accessioned2009-05-27T07:08:11Z
dc.date.available1998-05-22en_US
dc.date.available2009-05-27T07:08:11Z
dc.date.issued1998-05-22en_US
dc.description.abstractAssociation of HLA-DR2 genes/gene products has been shown with pulmonary tuberculosis (PTB) patients in India. In the present study, the influence of HLA-DR2 and non-DR2 genes/gene products on immunity to tuberculosis has been studied. Plasma samples of -DR2 positive patients (active and inactive TB) showed a higher antibody titre to Mycobacterium tuberculosis culture filtrate antigens than non-DR2 (-DR2 negative) patients. Immunoblot analysis revealed a trend towards an increased percentage of DR2 positive patients recognizing 38, 32/34 and 30/31 kDa antigens of M. tuberculosis than DR2 negative patients. A low spontaneous lymphoproliferative response (without antigen stimulation) was seen in HLA-DR2 positive active TB patients than HLA-DR2 negative patients. However, the antigen stimulated lymphocyte response was higher in the -DR2 positive patients (active and inactive TB) when compared to non-DR2 patients. Further, an inversional correlation between antibody titre and spontaneous as well as antigen induced lymphocyte response (measured by 3H thymidine uptake and expressed as counts per minute) was seen in HLA-DR2 positive active PTB patients than non-DR2 patients. The present study suggests that HLA-DR2 genes/gene products may be associated with a regulatory role in the mechanism of disease susceptibility to tuberculosis. The genes while augmenting the humoral immune response, they suppress the spontaneous and antigen induced lymphocyte response in -DR2 positive patients with active disease.en_US
dc.description.affiliationTuberculosis Research Centre, Chennai.en_US
dc.identifier.citationSelvaraj P, Uma H, Reetha AM, Xavier T, Prabhakar R, Narayanan PR. Influence of HLA-DR2 phenotype on humoral immunity & lymphocyte response to Mycobacterium tuberculosis culture filtrate antigens in pulmonary tuberculosis. Indian Journal of Medical Research. 1998 May; 107(): 208-17en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19450
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntibody Formation --geneticsen_US
dc.subject.meshAntigens, Bacterial --immunologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshFemaleen_US
dc.subject.meshHLA-DR2 Antigen --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytes --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMycobacterium Infections, Atypical --geneticsen_US
dc.subject.meshMycobacterium tuberculosis --immunologyen_US
dc.subject.meshTuberculosis, Pulmonary --geneticsen_US
dc.titleInfluence of HLA-DR2 phenotype on humoral immunity & lymphocyte response to Mycobacterium tuberculosis culture filtrate antigens in pulmonary tuberculosis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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