Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior.
| dc.contributor.author | Sethi, Bhawna | |
| dc.contributor.author | Pai, Trupti | |
| dc.contributor.author | Allam, Abhishek | |
| dc.contributor.author | Epari, Sridhar | |
| dc.date.accessioned | 2016-01-18T04:48:11Z | |
| dc.date.available | 2016-01-18T04:48:11Z | |
| dc.date.issued | 2015-10 | |
| dc.description.abstract | Inflammatory myofibroblastic tumor (IMT), an intermediate-grade neoplasm of myofibroblastic/fibroblastic differentiation, occurs commonly in children and young adults. It is characterized by anaplastic lymphoma kinase (ALK) gene rearrangement and overexpression of ALK-protein. However, aggressive behavior is more commonly associated with ALK-negativity rather than ALKpositivity. Pulmonary involvement is most common visceral location and carries minimal potential for distant metastasis. We present a case of 49-year-old female with pulmonary IMT of spindle cell sarcomatous histomorphology. Frequent mitoses and necrosis with characteristic cytoplasmic immunoreactivity for ALK-1 protein and ALK-gene rearrangement on fluorescence in-situ hybridization were noted. This case is unusual for occurrence in higher age-group of fifth decade, sarcomatous histomorphology at presentation (rather than transformation) and metastases to distant sites despite ALK-protein overexpression and gene rearrangement. | en_US |
| dc.identifier.citation | Sethi Bhawna, Pai Trupti, Allam Abhishek, Epari Sridhar. Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior. Indian Journal of Pathology & Microbiology. 2015 Oct-Dec 58(4): 509-512. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/170510 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2015;volume=58;issue=4;spage=509;epage=512;aulast=Sethi | en_US |
| dc.subject | Anaplastic lymphoma kinase gene | en_US |
| dc.subject | anaplastic lymphoma kinase-protein | en_US |
| dc.subject | crizotinib | en_US |
| dc.subject | fluorescence in-situ hybridization | en_US |
| dc.subject | inflammatory myofibroblastic sarcoma | en_US |
| dc.title | Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior. | en_US |
| dc.type | Article | en_US |