CALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern.
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Date
2011-01
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Abstract
Rearrangements of the mixed lineage leukemia (MLL) gene at 11q23 commonly occur in infants with CALLA negative B lymphoblastic leukemia (B-ALL). Most often, these are detected by conventional karyotyping; however, fluorescent in-situ hybridization (FISH) with the help of a dual-color break-apart probe is used to identify cryptic translocations. When there is an MLL gene translocations the usual FISH signal pattern is 1 red-1 yellow fusion signal pattern We present a case of an infant with CALLA negative precursor B-ALL with a characteristic translocations t(4;11) (q21;q23),however,with an unusual MLL FISH signal pattern.
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Keywords
B lymphoblastic leukemia, CALLA negative, conventional karyotyping, fluorescent in-situ hybridization, mixed lineage leukemia gene
Citation
Devi Sandhya G, Goyal Manu, Ramakrishna N V S S, Murthy S Sudha. CALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern. Indian Journal of Pathology & Microbiology. 2011 Jan-Mar 54(1): 176-179.