Clinical features and prognostic factors of early breast cancer at a major cancer center in North India.

Simple item page
dc.contributor.authorRaina, Vinoden_US
dc.contributor.authorBhutani, Manishaen_US
dc.contributor.authorBedi, Rajeeven_US
dc.contributor.authorSharma, Atulen_US
dc.contributor.authorDeo, Suryanarayana Ven_US
dc.contributor.authorShukla, Nootan Ken_US
dc.contributor.authorMohanti, Bidhu Kalyanen_US
dc.contributor.authorRath, Goura Ken_US
dc.date.accessioned2009-05-28T07:17:27Z
dc.date.available2009-05-28T07:17:27Z
dc.date.issued2005-01-05en_US
dc.description.abstractBACKGROUND: Data on the clinical profile of early breast cancer (EBC) from India is scant. Due to differences in genetics, environment, lifestyle, socio-demographic structure and ethnicity, the presentation and behavior of breast cancer in India may be different. AIMS: To analyze the clinical presentation and outcome of EBC patients. SETTINGS AND DESIGN: A single center retrospective study. MATERIALS AND METHODS: Data from 487 EBC patients registered and treated at our institute from 1993 through 1999 were analyzed. Cox's multivariate regression test was used to determine prognostic factors for overall and disease-free survival (OS & DFS). RESULTS: The median age was 47 years and 49.7% patients were pre-menopausal. Ninety-six per cent patients presented with a lump. Stages I, IIa, and IIb comprised 7.8%, 38.8%, and 47.6% respectively. Only 11.3% patients opted for breast-conserving surgery (BCS) while the remaining 88.7% underwent modified radical mastectomy (MRM). Adjuvant chemotherapy was administered to 275 (56.5%), and radiotherapy to 146 (29.9%). Estrogen receptor status was known in 173, of whom 93 (53.7%) were positive. Most patients were prescribed Tamoxifen for 5 years. At a median follow-up of 48 months, 126 (25.9%) patients had relapsed (systemic 107, loco-regional 19) and 94 (19.3%) had died. Five-year DFS and OS were 73% and 78%, respectively. On multivariate analysis, four positive nodes adversely influenced survival (P< 0.01). CONCLUSIONS: The median age at presentation was 47 years, significantly lower than most Western figures. The majority (86.4%) had a lump size > two cm. BCS was done in only 11% and the rest underwent MRM. Nodal involvement was the significant prognostic factor.en_US
dc.description.affiliationDepartment of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110029, India. vinodraina@hotmail.comen_US
dc.identifier.citationRaina V, Bhutani M, Bedi R, Sharma A, Deo SV, Shukla NK, Mohanti BK, Rath GK. Clinical features and prognostic factors of early breast cancer at a major cancer center in North India. Indian Journal of Cancer. 2005 Jan-Mar; 42(1): 40-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/51146
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBreast Neoplasms --diagnosisen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMedical Recordsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Local --diagnosisen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshNeoplasms, Hormone-Dependent --diagnosisen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSurvival Analysisen_US
dc.titleClinical features and prognostic factors of early breast cancer at a major cancer center in North India.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Cancer