Correlation of lipoprotein (a) levels and plaque morphology in very young acute coronary syndrome patients using optical coherence tomography

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dc.contributor.authorChandra, Sharaden_US
dc.contributor.authorNagar, Saurabhen_US
dc.contributor.authorShukla, Ayushen_US
dc.contributor.authorChaudhary, Gauraven_US
dc.contributor.authorSharma, Akhilen_US
dc.contributor.authorPradhan, Akshyayaen_US
dc.contributor.authorBhandari, Monikaen_US
dc.contributor.authorVishwakarma, Praveshen_US
dc.contributor.authorSethi, Rishien_US
dc.contributor.authorNarain, Varun Shankaren_US
dc.contributor.authorDwivedi, Sudhanshu Kumaren_US
dc.date.accessioned2023-07-21T11:36:55Z
dc.date.available2023-07-21T11:36:55Z
dc.date.issued2022-10
dc.description.abstractIntroduction: Levels of lipoprotein (LP) (a) are useful marker for risk stratification of cardiovascular disease. This genetic biomarker is suggestive of patient predisposition to acute coronary event. The present study was to study correlation of LP(a) levels and plaque morphology in very young patients (<35 years) with acute coronary syndrome (ACS). Methods: A prospective, single-center, observational study consisting of very young patients with ACS and fit for optical coherence tomography (OCT) guided invasive coronary angiography was conducted at tertiary-care centre. LP(a) levels were compared between healthy controls and very young ACS patients. Correlation of LP(a) levels and plaque characteristics in very young ACS patients was done using OCT imaging. Results: Out of enrolled 80 subjects, 40 were very young ACS and 40 were matched healthy controls. In very young patients, plaque rupture and erosion were mechanism of ACS in 67.5% and 32.5% patients, respectively. Mean levels of LP(a) were 28.10 ± 13.96 nmol/l in healthy controls and 47.19 ± 29.85 nmol/l in very young patients with ACS (p ¼ 0.022). Among very young ACS patients, patients with LP(a) levels<75 nmol/l and 75 nmol/l had mean thin cap fibroatheroma thickness of 117.08 ± 52.542 mm and 95.00 ± 36.286 mm, respectively (p ¼ 0.2355). Conclusion: Higher levels of LP(a) were seen in younger patients with ACS compared with matched healthy individuals. Plaque rupture was the commonest mechanism of ACS in very young ACS patients. Patients with high LP(a) levels had lesser thickness of fibrous cap in OCT imaging compared with low levels of LP(a).en_US
dc.identifier.affiliationsDepartment of Cardiology, King George's Medical University, Shah Mina Rd, Chowk, Lucknow, Uttar Pradesh, 226003, Indiaen_US
dc.identifier.citationChandra Sharad, Nagar Saurabh, Shukla Ayush, Chaudhary Gaurav, Sharma Akhil, Pradhan Akshyaya, Bhandari Monika, Vishwakarma Pravesh, Sethi Rishi, Narain Varun Shankar, Dwivedi Sudhanshu Kumar. Correlation of lipoprotein (a) levels and plaque morphology in very young acute coronary syndrome patients using optical coherence tomography. Indian Heart Journal. 2022 Oct; 74(5): 357-362en_US
dc.identifier.issn0019-4832
dc.identifier.issn2213-3763
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220925
dc.languageenen_US
dc.publisherCardiological Society of Indiaen_US
dc.relation.issuenumber5en_US
dc.relation.volume74en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2022.09.001en_US
dc.subjectAcute coronary syndromeen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectLipoprotein (a)en_US
dc.subjectOptical coherence tomographyen_US
dc.subjectPlaqueen_US
dc.titleCorrelation of lipoprotein (a) levels and plaque morphology in very young acute coronary syndrome patients using optical coherence tomographyen_US
dc.typeJournal Articleen_US
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