Detection of antibodies against Opisthorchis viverrini in patients before and after treatment with praziquantel.

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dc.contributor.authorThammapalerd, Nen_US
dc.contributor.authorTharavanij, Sen_US
dc.contributor.authorNacapunchai, Den_US
dc.contributor.authorBunnag, Den_US
dc.contributor.authorRadomyos, Pen_US
dc.contributor.authorPrasertsiriroj, Ven_US
dc.date.accessioned2009-05-27T16:02:49Z
dc.date.available2009-05-27T16:02:49Z
dc.date.issued1988-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractLevels of antibody in sera of 78 patients with opisthorchiasis, 30 patients with other liver diseases, 10 patients with schistosomiasis and 30 healthy individuals were compared using three serodiagnostic tests, namely indirect haemagglutination (IHA), enzyme-linked immunosorbent assay (ELISA) and lectin immuno test (LIT). The geometric mean reciprocal titer in sera of opisthorchiasis patients was significantly higher than patients with other diseases, patients with schistosomiasis and healthy individuals (p less than 0.00001). After treatment with praziquantel, the antibody titers were decreased and became lowest 120 days after treatment. A statistically significant decrease from the pre-treatment sample was observed only at 120 days after infection and not earlier and only with ELISA (p = 0.03) and not with IHA and LIT (p greater than 0.05). Even with ELISA, significant decrease in antibody titer was apparent only when the pre-treatment sera had high enough antibody titer. ELISA was therefore better than the other two tests for the assessment of cure provided that the titer of pre-treatment sera was high.en_US
dc.description.affiliationDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationThammapalerd N, Tharavanij S, Nacapunchai D, Bunnag D, Radomyos P, Prasertsiriroj V. Detection of antibodies against Opisthorchis viverrini in patients before and after treatment with praziquantel. The Southeast Asian Journal of Tropical Medicine and Public Health. 1988 Mar; 19(1): 101-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34288
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Helminth --analysisen_US
dc.subject.meshConcanavalin A --diagnostic useen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshHemagglutination Testsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Diseases --immunologyen_US
dc.subject.meshOpisthorchiasis --diagnosisen_US
dc.subject.meshOpisthorchis --immunologyen_US
dc.subject.meshPraziquantel --therapeutic useen_US
dc.subject.meshSchistosomiasis japonica --immunologyen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshSerologic Tests --methodsen_US
dc.subject.meshThailanden_US
dc.titleDetection of antibodies against Opisthorchis viverrini in patients before and after treatment with praziquantel.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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