Ultrastructural changes in mild gastroesophageal reflux disease: results of a pilot study.

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dc.contributor.authorPanicker, K Nen_US
dc.contributor.authorMohandas, K Men_US
dc.contributor.authorSwaroop, V Sen_US
dc.contributor.authorKrishnamurthy, Sen_US
dc.date.accessioned1994-07-01en_US
dc.date.accessioned2009-05-29T02:27:52Z
dc.date.available1994-07-01en_US
dc.date.available2009-05-29T02:27:52Z
dc.date.issued1994-07-01en_US
dc.description.abstractFew studies have examined the ultrastructural changes in mild reflux esophagitis. Endoscopic esophageal biopsies were obtained from 10 patients with reflux symptoms and mild endoscopic esophagitis (grade 0:3 patients, grade I: 7 patients) and 9 patients with erosive esophagitis (grade II-IV), at least 5 cm above the Z line. The biopsies were evaluated by light and transmission electron microscopy. Ultrastructural changes were present in one patient with grade 0, 7 with grade I and 9 with grade II-IV esophagitis. Four of the 10 patients with grade 0-I esophagitis and 6 of 9 with grade II-IV esophagitis had light microscopic abnormalities. The ultrastructural abnormalities in patients with mild esophagitis were seen in the cell membrane, cytoplasmic organelles, desmosomes, and nuclei of all the three layers of esophageal mucosa and the basal lamina. Ultrastructural studies by transmission electron microscopy on endoscopic pinch biopsies may be a sensitive research tool to study the pathogenesis of mild reflux esophagitis.en_US
dc.description.affiliationDivision of Cell Biology, Cancer Research Institute, Tata Memorial Hospital, Bombay.en_US
dc.identifier.citationPanicker KN, Mohandas KM, Swaroop VS, Krishnamurthy S. Ultrastructural changes in mild gastroesophageal reflux disease: results of a pilot study. Indian Journal of Gastroenterology. 1994 Jul; 13(3): 89-91en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64172
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshEsophagus --ultrastructureen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastroesophageal Reflux --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPilot Projectsen_US
dc.titleUltrastructural changes in mild gastroesophageal reflux disease: results of a pilot study.en_US
dc.typeJournal Articleen_US
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