Diffuse Large B-cell Lymphoma Presenting as Empyema: A Case Report and Review of Literature

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dc.contributor.authorRasheeka, VPen_US
dc.contributor.authorJain, Sen_US
dc.contributor.authorAgarwal, Sen_US
dc.contributor.authorBajad, Pen_US
dc.contributor.authorPahuja, Sen_US
dc.contributor.authorKhanna, A.en_US
dc.date.accessioned2025-05-09T11:00:45Z
dc.date.available2025-05-09T11:00:45Z
dc.date.issued2024-12
dc.description.abstractAim and background: Non-Hodgkin lymphoma (NHL) is the most common hematological malignancy, and diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype. It is a highly aggressive B-cell lymphoma resulting in the clonal proliferation of a germinal or post-germinal malignant B cell. The diagnosis is confirmed by biopsy of the affected node/extra-nodal site. Pleural involvement in lymphoma has a diverse presentation; however, presentation as an empyema, as in our case, has not been reported previously. Case description: We present a very rare case of a young, previously healthy female patient who presented with a right-sided pleural collection, who was initially suspected to have empyema due to characteristic findings on ultrasonography and pleural fluid appearance. Her pleural fluid cytology revealed atypical cells and was later diagnosed with an underlying anterior mediastinal mass confirmed to be DLBCL. Conclusion: Empyema may be the first harbinger of malignancy, especially in young immunocompetent patients. Timely diagnosis may be challenging but it improves the prognosis of such patients. Clinical significance: In a TB-endemic country like India, a patient with empyema poses a diagnostic dilemma. Cytology/biopsy and immunohistochemistry aid in diagnosis in such cases. Imaging also plays a key role in tumor staging, therapeutic planning, and follow-up of patients.en_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad, Haryana, Indiaen_US
dc.identifier.citationRasheeka VP, Jain S, Agarwal S, Bajad P, Pahuja S, Khanna A.. Diffuse Large B-cell Lymphoma Presenting as Empyema: A Case Report and Review of Literature . The Indian Journal of Chest Diseases and Allied Sciences. 2024 Dec; 66(4): 140-142en_US
dc.identifier.issn0377-9343
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245835
dc.languageenen_US
dc.publisherJaypee Brothers Medical Publishers Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume66en_US
dc.source.urihttps://doi.org/10.5005/jp-journals-11007-0128en_US
dc.subjectCase reporten_US
dc.subjectDiffuse large B-cell lymphomaen_US
dc.subjectEmpyemaen_US
dc.subjectLymphomaen_US
dc.subjectPleural effusionen_US
dc.titleDiffuse Large B-cell Lymphoma Presenting as Empyema: A Case Report and Review of Literatureen_US
dc.typeJournal Articleen_US
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