Comparative analysis of fecal microflora of healthy full-term Indian infants born with different methods of delivery (vaginal vs cesarean): Acinetobacter sp. prevalence in vaginally born infants.
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Date
2012-12
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Abstract
In this study fecal microflora of human infants born through vaginal delivery (VB) and through cesarean section (CB)
were investigated using culture-independent 16S rDNA cloning and sequencing approach. The results obtained clearly
revealed that fecal microbiota of VB infants distinctly differ from those in their counterpart CB infants. The intestinal
microbiota of infants delivered by cesarean section appears to be more diverse, in terms of bacteria species, than the
microbiota of vaginally delivered infants. The most abundant bacterial species present in VB infants were
Acinetobacter sp., Bifidobacterium sp. and Staphylococcus sp. However, CB infant’s fecal microbiota was dominated
with Citrobacter sp., Escherichia coli and Clostridium difficile. The intestinal microbiota of cesarean section delivered
infants in this study was also characterized by an absence of Bifidobacteria species. An interesting finding of our study
was recovery of large number of Acinetobacter sp. consisting of Acinetobacter pittii (former Acinetobacter genomic
species 3), Acinetobacter junii and Acinetobacter baumannii in the VB infants clone library. Among these,
Acinetobacter baumannii is a known nosocomial pathogen and Acinetobacter pittii (genomic species 3) is recently
recognized as clinically important taxa within the Acinetobacter calcoaceticus–Acinetobacter baumannii (ACB)
complex. Although none of the infants had shown any sign of clinical symptoms of disease, this observation warrants
a closer look.
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Keywords
Gastrointestinal tract, gut microbiota, mode of delivery, 16S rRNA
Citation
Pandey Prashant Kumar, Verma Pankaj, Kumar Himanshu, Bavdekar Ashish, Patole Milind S, Shouche Yogesh S. Comparative analysis of fecal microflora of healthy full-term Indian infants born with different methods of delivery (vaginal vs cesarean): Acinetobacter sp. prevalence in vaginally born infants. Journal of Biosciences. 2012 Dec; 37 (6): 989-998.