Urine levels of rifampicin & isoniazid in asymptomatic HIV-positive individuals.

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dc.contributor.authorRamachandran, Geethaen_US
dc.contributor.authorHemanth Kumar, A Ken_US
dc.contributor.authorSarala, Ken_US
dc.contributor.authorPadmapriyadarsini, Cen_US
dc.contributor.authorAnitha, Sen_US
dc.contributor.authorTharani, C Ben_US
dc.contributor.authorKumaraswami, Ven_US
dc.contributor.authorSwaminathan, Soumyaen_US
dc.date.accessioned2007-06-21en_US
dc.date.accessioned2009-05-27T08:50:54Z
dc.date.available2007-06-21en_US
dc.date.available2009-05-27T08:50:54Z
dc.date.issued2007-06-21en_US
dc.description.abstractBACKGROUND & OBJECTIVE: AIDS and its associated gastrointestinal complications may impair the absorption of anti-tuberculosis (TB) drugs. Impaired absorption of anti-TB drugs could lead to low drug exposure, which might contribute to acquired drug resistance and reduced effectiveness of anti-TB treatment. The aim of this study was to obtain information on the status of absorption of rifampicin (RMP) and isoniazid (INH) in asymptomatic HIV- positive individuals, who are less immunocompromised. The D-xylose absorption test was also carried out to assess the absorptive capacity of intestive. METHODS: The absorption of RMP, INH and D-xylose was studied in 15 asymptomatic HIV-positive individuals with CD4 cell counts>350 cells/mm3 and 16 healthy volunteers, after oral administration of single doses of RMP (450 mg), INH (300 mg) and D-xylose (5 g). Urine was collected up to 8 h after drug administration. Percentage dose of the drugs and their metabolites and D-xylose excreted in urine were calculated. RESULTS: A significant reduction in the urinary excretion of INH and D-xylose in HIV-positive persons compared to healthy volunteers was observed. The per cent dose of RMP and its metabolite, desacetyl RMP was also lower in HIV-positive persons compared to healthy volunteers, but this difference was not statistically significant. INTERPRETATION & CONCLUSION: Decreased urinary excretion of D-xylose and INH are suggestive of intestinal malabsorption in HIV-positive individuals. HIV infection could cause malabsorption of anti-TB drugs even at an early stage of the disease. The clinical implications of these findings need to be confirmed in larger studies.en_US
dc.description.affiliationTuberculosis Research Centre (ICMR), Chennai, India.en_US
dc.identifier.citationRamachandran G, Hemanth Kumar AK, Sarala K, Padmapriyadarsini C, Anitha S, Tharani CB, Kumaraswami V, Swaminathan S. Urine levels of rifampicin & isoniazid in asymptomatic HIV-positive individuals. Indian Journal of Medical Research. 2007 Jun; 125(6): 763-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25840
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntitubercular Agents --urineen_US
dc.subject.meshCD4-Positive T-Lymphocytes --drug effectsen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHIV Infections --complicationsen_US
dc.subject.meshHIV Seropositivityen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunocompromised Hosten_US
dc.subject.meshIsoniazid --urineen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshRifampin --urineen_US
dc.subject.meshTuberculosis --complicationsen_US
dc.subject.meshXylose --chemistryen_US
dc.titleUrine levels of rifampicin & isoniazid in asymptomatic HIV-positive individuals.en_US
dc.typeJournal Articleen_US
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