Causes of corneal graft failure in India.

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dc.contributor.authorDandona, Len_US
dc.contributor.authorNaduvilath, T Jen_US
dc.contributor.authorJanarthanan, Men_US
dc.contributor.authorRao, G Nen_US
dc.date.accessioned1998-09-23en_US
dc.date.accessioned2009-05-29T08:10:48Z
dc.date.available1998-09-23en_US
dc.date.available2009-05-29T08:10:48Z
dc.date.issued1998-09-23en_US
dc.description.abstractThe success of corneal grafting in visual rehabilitation of the corneal blind in India depends on survival of the grafts. Understanding the causes of graft failure may help reduce the risk of failure. We studied these causes in a series of 638 graft failures at our institution. Multivariate logistic regression analysis was used to evaluate the association of particular causes of graft failure with indications for grafting, socioeconomic status, age, sex, host corneal vascularization, donor corneal quality, and experience of surgeon. The major causes of graft failure were allograft rejection (29.2%), increased intraocular pressure (16.9%), infection excluding endophthalmitis (15.4%), and surface problems (12.7%). The odds of infection causing graft failure were significantly higher in patients of lower socioeconomic status (odds ratio 2.45, 95% CI 1.45-4.15). Surface problems as a cause of graft failure was significantly associated with grafts done for corneal scarring or for regrafts (odds ratio 3.36, 95% CI 1.80-6.30). Increased intraocular pressure as a cause of graft failure had significant association with grafts done for aphakic or pseudophakic bullous keratopathy, congenital conditions or glaucoma, or regrafts (odds ratio 2.19, 95% CI 1.25-3.84). Corneal dystrophy was the indication for grafting in 12 of the 13 cases of graft failure due to recurrence of host disease. Surface problems, increased intraocular pressure, and infection are modifiable risk factors that are more likely to cause graft failure in certain categories of patients in India. Knowledge about these associations can be helpful in looking for and aggressively treating these modifiable risk factors in the at-risk categories of corneal graft patients. This can possibly reduce the chance of graft failure.en_US
dc.description.affiliationPublic Health Ophthalmology Service, L.V. Prasad Eye Institute, Hyderabad, India. dandona@lvpeye.stph.neten_US
dc.identifier.citationDandona L, Naduvilath TJ, Janarthanan M, Rao GN. Causes of corneal graft failure in India. Indian Journal of Ophthalmology. 1998 Sep; 46(3): 149-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/70182
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshChilden_US
dc.subject.meshCorneal Diseases --surgeryen_US
dc.subject.meshCorneal Transplantation --adverse effectsen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGraft Rejection --diagnosisen_US
dc.subject.meshGraft Survivalen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTreatment Failureen_US
dc.titleCauses of corneal graft failure in India.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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