Apolipoprotein(a) polymorphism and its association with plasma lipoprotein(a) levels: a north Indian study.

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dc.contributor.authorVasisht, Sen_US
dc.contributor.authorGulati, Ren_US
dc.contributor.authorSrivastava, L Men_US
dc.contributor.authorNarang, Ren_US
dc.contributor.authorChopra, Ven_US
dc.contributor.authorSrivastava, Nen_US
dc.contributor.authorAgarwal, D Pen_US
dc.contributor.authorManchanda, S Cen_US
dc.date.accessioned2000-03-14en_US
dc.date.accessioned2009-05-27T04:22:38Z
dc.date.available2000-03-14en_US
dc.date.available2009-05-27T04:22:38Z
dc.date.issued2000-03-14en_US
dc.description.abstractElevated levels of lipoprotein(a) has been regarded as an independent risk factor for coronary, peripheral and cerebral atherosclerosis. The enormous intra-personal variation in the plasma concentration of lipoprotein(a) is almost entirely controlled by the apolipoprotein(a) i.e. gene locus on the chromosome 6q 26-27. The apolipoprotein(a) molecule is highly polymorphic and is known to exist in multiple, genetically determined isoforms. These polymorphisms may be responsible for difference in promoter activity, variable size of apolipoprotein(a) and thereby variation in plasma lipoprotein(a) concentration. We studied the effect of two types of polymorphisms, (i) variation in length of the pentanucleotide repeat in the 5' flanking region starting -1373 bp upstream of AUG codon, and (ii) the Kringle-4 type 2 size polymorphism, on plasma lipoprotein(a) levels in North Indian population. The study group consisted of 88 angiographically assessed male coronary artery disease patients (age range 30-70 years) and 83 age- and sex-matched healthy controls. The pentanucleotide repeat polymorphism was analysed using polymerase chain reaction. In all, 8/11 pentanucleotide repeat isoforms were observed. Using SDS-agarose gel electrophoresis and immunoblotting isoforms having 12-50 Kringle-4 type 2 repeats were detected. Our study indicates a strong association of elevated plasma lipoprotein(a) concentration with coronary artery disease. An inverse correlation was seen between lipoprotein concentration and isoform size for both the pentanucleotide repeat polymorphism and the Kringle-4 type 2 polymorphisms; statistically significant difference (p = 0.001) was, however, observed only for the later.en_US
dc.description.affiliationDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationVasisht S, Gulati R, Srivastava LM, Narang R, Chopra V, Srivastava N, Agarwal DP, Manchanda SC. Apolipoprotein(a) polymorphism and its association with plasma lipoprotein(a) levels: a north Indian study. Indian Heart Journal. 2000 Mar-Apr; 52(2): 165-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4328
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshApolipoproteins A --geneticsen_US
dc.subject.meshCoronary Disease --ethnologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshLipoprotein(a) --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.titleApolipoprotein(a) polymorphism and its association with plasma lipoprotein(a) levels: a north Indian study.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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