Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes.

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dc.contributor.authorSharma, Ken_US
dc.contributor.authorKhosla, P Ken_US
dc.contributor.authorTiwari, H Ken_US
dc.contributor.authorSharma, R Ken_US
dc.contributor.authorBajaj, J Sen_US
dc.date.accessioned1991-10-01en_US
dc.date.accessioned2009-05-29T08:15:39Z
dc.date.available1991-10-01en_US
dc.date.available2009-05-29T08:15:39Z
dc.date.issued1991-10-01en_US
dc.description.abstractJuvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. In the present study, there was statistically a significant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy. Though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen which some authors have reported.en_US
dc.description.affiliationDr. Rajendra Prasad Centre for Ophthalmic Sciences, Department of Medicine, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSharma K, Khosla PK, Tiwari HK, Sharma RK, Bajaj JS. Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes. Indian Journal of Ophthalmology. 1991 Oct-Dec; 39(4): 174-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/70273
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshDiabetes Mellitus, Type 1 --blooden_US
dc.subject.meshDiabetic Retinopathy --blooden_US
dc.subject.meshHLA-B Antigens --blooden_US
dc.subject.meshHistocompatibility Testingen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin Antibodies --blooden_US
dc.subject.meshRadioimmunoassayen_US
dc.titleAnti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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