Venous thromboembolism: the intricacies.

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dc.contributor.authorDutta, T Ken_US
dc.contributor.authorVenugopal, Ven_US
dc.date.accessioned2009-01-27en_US
dc.date.accessioned2009-06-02T10:00:17Z
dc.date.available2009-01-27en_US
dc.date.available2009-06-02T10:00:17Z
dc.date.issued2009-01-27en_US
dc.description56 references.en_US
dc.description.abstractVenous thromboembolism (VTE) has been a subject of great interest of late. Since Rudolph Virchow described the famous Virchow's triad in 1856, there have been rapid strides in the understanding of the pathogenesis and factors responsible for it. Discovery of various thrombophilic factors, both primary and acquired, in the last 40 years has revolutionized prognostication and management of this potentially life-threatening condition due to its associated complication of pulmonary thromboembolism. Detailed genetic mapping and linkage analyses have been underlining the fact that VTE is a multifactorial disorder and a complex one. There are many gene-gene and gene-environment interactions that alter and magnify the clinical picture in this disorder. Point in case is pregnancy, where the risk of VTE is 100-150 times increased in the presence of Factor V Leiden, prothrombin mutation (Prothrombin 20210A) and antithrombin deficiency. Risk of VTE associated with long-haul air flight has now been well recognized. Thrombotic events associated with antiphospholipid syndrome (APS) are 70% venous and 30% arterial. Deep venous thrombosis and pulmonary embolism are the most common venous events, though unusual cases of catastrophes due to central vein thrombosis like renal vein thrombosis and Budd-Chiari syndrome (catastrophic APS) may occur.en_US
dc.description.affiliationDepartment of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India. tkduttajipmer@yahoo.co.uken_US
dc.identifier.citationDutta TK, Venugopal V. Venous thromboembolism: the intricacies. Journal of Postgraduate Medicine. 2009 Jan-Mar; 55(1): 55-64en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/115216
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAntiphospholipid Syndrome --complicationsen_US
dc.subject.meshAntithrombin III Deficiency --complicationsen_US
dc.subject.meshFactor V --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMutation --geneticsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Hematologic --geneticsen_US
dc.subject.meshProthrombin --geneticsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTravelen_US
dc.subject.meshVenous Thromboembolism --etiologyen_US
dc.titleVenous thromboembolism: the intricacies.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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