Cytomorphometric analysis of buccal mucosal cells in iron deficiency anemia: A cross-sectional study

Simple item page
dc.contributor.authorSwati, S Patilen_US
dc.contributor.authorSangeeta, J Palaskaren_US
dc.contributor.authorBindiya, R Narangen_US
dc.contributor.authorRasika, B Pawaren_US
dc.contributor.authorPargatsingh, T Kathuriyaen_US
dc.contributor.authorYogesh, S Khandalkaren_US
dc.date.accessioned2025-05-09T09:57:05Z
dc.date.available2025-05-09T09:57:05Z
dc.date.issued2024-03
dc.description.abstractBackground: Worldwide, at any given moment, more individuals have iron deficiency anemia (IDA) than any other health problems. Very few studies have been conducted to evaluate changes in oral mucosa in IDA. The present study is undertaken for cytomorphometric analysis of buccal mucosal cells in IDA. Nuclear diameter (ND), cell diameter (CD), nuclear area (NA), cell area (CA), and nuclear?cytoplasmic ratio (N/C) are measured and compared in buccal mucosal cells of IDA patients and controls. Aims: To evaluate cytomorphometric changes in epithelial cells of oral mucosa in IDA and to compare these changes with the controls. Settings and Design: A cross?sectional study. Methods and Materials: Forty cases of IDA and forty cases of control group were selected for the study. IDA cases were diagnosed with decreased Hb level, MCV, MCH, MCHC and confirmed by decreased serum iron and increased total iron?binding capacity levels. Cytomorphometric analysis of buccal mucosa was performed to study CA, CD, NA, ND, and N/C ratio. Statistical Analysis Used: Statistical analysis was done using t? test in SPSS software version 4. Result: Results of our study showed increased cell area, cell diameter, nuclear area, nuclear diameter, and nuclear?cytoplasmic ratio in anemic group as compared to controls. Conclusion: The study suggests that individuals with IDA regardless of clinically visible oral lesions show cytological changes in oral mucosal epithelium. Knowledge of quantitative alterations in oral epithelial cells of IDA patients is important as these alterations are similar to those seen in precancerous and radiation?induced changes. Cytomorphometry is an efficient tool to understand the extent of cellular changes that occur in oral epithelial cells in IDA.en_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsGeneral Dental Practitioner, Dr. D. Y. Patil Medical College, Hospital and Research Center, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Orthopedics, Dr. D. Y. Patil Medical College, Hospital and Research Center, Pune, Maharashtra, Indiaen_US
dc.identifier.citationSwati S Patil, Sangeeta J Palaskar, Bindiya R Narang, Rasika B Pawar, Pargatsingh T Kathuriya, Yogesh S Khandalkar. Cytomorphometric analysis of buccal mucosal cells in iron deficiency anemia: A cross-sectional study. Indian Journal of Pathology & Microbiology. 2024 Mar; 67(1): 56-61en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245470
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume67en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_43_22en_US
dc.subjectBuccal mucosaen_US
dc.subjectcytomorphometryen_US
dc.subjectiron deficiency anemiaen_US
dc.titleCytomorphometric analysis of buccal mucosal cells in iron deficiency anemia: A cross-sectional studyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijpm2024v67n1p56.pdf
Size:
1.28 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Pathology & Microbiology