Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: A systematic review.

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dc.contributor.authorSingh, Sanjay
dc.date.accessioned2012-08-31T05:42:27Z
dc.date.available2012-08-31T05:42:27Z
dc.date.issued2011-07
dc.description.abstractBackground: Pemphigus, bullous pemphigoid, and epidermolysis bullosa acquisita are autoimmune diseases of skin associated with considerable morbidity and sometimes mortality. There is no cure for these diseases. Aims: To summarize evidence-based treatments for these diseases by performing a systematic review. Methods: The research protocol included the following steps: identification of databases to be searched, defining search strategy, searching the databases for references, first-stage screening of the abstracts, second-stage screening of full texts of articles identified after the first-stage screening, data extraction from the identified articles after second-stage screening, quality appraisal of the studies using the Delphi list, and summarizing the findings. Results: No randomized controlled trials of interventions in pemphigus vegetans, pemphigus erythematosus, and epidermolysis bullosa acquisita could be found. After the second-stage screening, 12 randomized controlled trials were analyzed, which included patients with pemphigus vulgaris or pemphigus vulgaris and pemphigus foliaceus, and 7 which included patients with bullous pemphigoid. Conclusions: Number of high-quality randomized controlled trials conducted on pemphigus and bullous pemphigoid is small. Oral corticosteroid along with a steroid-sparing agent appears to be the most effective treatment for pemphigus. Azathioprine may be most effective as a steroid-sparing agent. Topical corticosteroid therapy (as studied) is effective for bullous pemphigoid and appears to be superior to oral corticosteroid for extensive disease. Some suggestions about future research are made.en_US
dc.identifier.citationSingh Sanjay. Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: A systematic review. Indian Journal of Dermatology, Venereology and Leprology. 2011 Jul-Aug; 77(4): 456-469.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/140883
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2011;volume=77;issue=4;spage=456;epage=469;aulast=Singhen_US
dc.subjectBullous pemphigoiden_US
dc.subjectevidence-based treatmenten_US
dc.subjectinterventionsen_US
dc.subjectpemphigusen_US
dc.subjectreviewen_US
dc.subjectsystematic reviewen_US
dc.subjecttreatmenten_US
dc.titleEvidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: A systematic review.en_US
dc.typeArticleen_US
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