Interpenetrating polymer network of cross-linked blend microspheres for controlled release of Acebutolol HCl.

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dc.contributor.authorRamakrishna, P
dc.contributor.authorMallikarjuna, B
dc.contributor.authorBabu, A Chandra
dc.contributor.authorSudhakar, P
dc.contributor.authorRao, K Chowdoji
dc.contributor.authorSubha, M C S
dc.date.accessioned2014-05-14T12:40:08Z
dc.date.available2014-05-14T12:40:08Z
dc.date.issued2011-08
dc.description.abstractCarbohydrate polymeric blend microspheres consisting of chitosan (CS) and poly (vinyl alcohol) (PVA) were prepared by water-in-oil (W/O) emulsion method. These microspheres were crosslinked with glutaraldehyde and loaded with Acebutolol HCl, an anti hypertensive drug. The microspheres were characterized by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-Ray diffraction (X-RD) and Scanning electron microscopy (SEM).The FTIR spectroscopy explains the crosslinking between the CS-PVA. DSC& X-RD indicated the molecular level distribution of Acebutolol HCl drug in the polymer matrix. The SEM of the microspheres suggested the formation of spherical particles. Swelling experiments on the microspheres provided important information on drug diffusion properties. Release data have been analyzed using an empirical equation to understand the nature of transport of drug containing solution through the polymeric matrices. The controlled release characteristic of the matrices for Acebutolol HCl was investigated in pH 7.4 media. The results indicate that the drug was released in a controlled manner up to 10 h.en_US
dc.identifier.citationRamakrishna P, Mallikarjuna B, Babu A Chandra, Sudhakar P, Rao K Chowdoji, Subha M C S. Interpenetrating polymer network of cross-linked blend microspheres for controlled release of Acebutolol HCl. Journal of Applied Pharmaceutical Science. 2011 Aug; 1(6): 212-219.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150882
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=156en_US
dc.subjectChitosan (CS)en_US
dc.subjectPoly (Vinyl alcohol) (PVA)en_US
dc.subjectmicrospheresen_US
dc.subjectAcebutolol HClen_US
dc.subjectdrug deliveryen_US
dc.subjectblenden_US
dc.subjectcrosslinkingen_US
dc.titleInterpenetrating polymer network of cross-linked blend microspheres for controlled release of Acebutolol HCl.en_US
dc.typeArticleen_US
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