Serum Periostin Level in Children with Asthma
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Date
2023-05
Journal Title
Journal ISSN
Volume Title
Publisher
Dr. K C Chaudhuri Foundation
Abstract
Objectives To determine the average serum periostin level in children with asthma between 6 and 16 y of age, and to fnd out if the levels correlated with markers of eosinophilic infammation, asthma control, and severity. Methods Children under follow-up at a tertiary care centre were enrolled. Children with conditions causing elevated serum periostin other than asthma, or history of systemic steroid use in the past 6 mo were excluded. Serum total IgE and periostin were estimated by ELISA. Results The median (IQR) serum periostin level was 52.6 (45.4, 58.3) ng/mL. Levels did not vary with age, gender, duration of symptoms, positive family history, or history of exacerbations in the last 6 mo. There was no signifcant correlation with anthropometric parameters or their z scores, or markers of eosinophilic infammation in blood including serum total IgE, eosinophil percentage or absolute eosinophil count. There was no diference in median periostin levels of children with diferent asthma symptom control or asthma severity. Conclusions In a group of 26 Indian children with physician-diagnosed asthma, serum periostin showed no signifcant correlation to markers of eosinophilic infammation.
Description
Keywords
Biomarker, Childhood asthma, Eosinophilic inflammation, Noninvasive test, T2-high pathway
Citation
Kumar Ketan, Singh Meenu, Mathew Joseph L., Vaidya Pankaj C., Attri Savita Verma. Serum Periostin Level in Children with Asthma. Indian Journal of Pediatrics. 2023 May; 90(5): 438–442