HIV-1 drug resistance among untreated patients in India: Current status.

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dc.contributor.authorPachamuthu, Ben_US
dc.contributor.authorShanmugam, Sen_US
dc.contributor.authorNagalingeswaran, Ken_US
dc.contributor.authorSolomon, S Sen_US
dc.contributor.authorSolomon, Sen_US
dc.contributor.authorSolomon, Sen_US
dc.date.accessioned2006-07-21en_US
dc.date.accessioned2009-06-02T12:20:19Z
dc.date.available2006-07-21en_US
dc.date.available2009-06-02T12:20:19Z
dc.date.issued2006-07-21en_US
dc.description36 references.en_US
dc.description.abstractHAART has dramatically improved survival and quality of life among people living with HIV and AIDS globally. However, drug resistant mutations of HIV are a great challenge to the benefits of HAART. Antiviral resistance can be mediated either by changes in the molecular target of therapy (the primary mechanism observed in HIV-1) or in other viral proteins that indirectly interfere with a drug's activity. Drug resistant mutations easily evolve in the presence of sub-optimal adherence. With the introduction of generic HAART, there has been a steep increase in the number of patients put on HAART in India. It should also be noted that since most patients pay for medications out of their own pockets, interruptions in therapy due to monetary constraints are not uncommon. There is little information on HIV drug resistance in resource constrained settings like India where the predominant circulating HIV-1 sub-type is C. The transmissibility of drug-resistant forms of the virus is also a major concern especially when formulating treatment guidelines. This article reviews published data available on the patterns of HIV-1 drug resistance among treatment naïve in India.en_US
dc.description.affiliationYRG Centre for AIDS Research and Education, Voluntary Health Services Campus, Taramani, Chennai-600113, India. bala@yrgcare.orgen_US
dc.identifier.citationPachamuthu B, Shanmugam S, Nagalingeswaran K, Solomon SS, Solomon S, Solomon S. HIV-1 drug resistance among untreated patients in India: Current status. Journal of Postgraduate Medicine. 2006 Jul-Sep; 52(3): 183-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/116838
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAcquired Immunodeficiency Syndrome --drug therapyen_US
dc.subject.meshAnti-HIV Agents --economicsen_US
dc.subject.meshAntiretroviral Therapy, Highly Activeen_US
dc.subject.meshDrug Resistance, Viral --geneticsen_US
dc.subject.meshHIV-1 --classificationen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMutationen_US
dc.subject.meshPatient Complianceen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshReverse Transcriptase Inhibitors --pharmacologyen_US
dc.titleHIV-1 drug resistance among untreated patients in India: Current status.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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