Human immune responses to dengue viruses.

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dc.contributor.authorKurane, Ien_US
dc.contributor.authorInnis, B Len_US
dc.contributor.authorNimmannitya, Sen_US
dc.contributor.authorNisalak, Aen_US
dc.contributor.authorRothman, A Len_US
dc.contributor.authorLivingston, P Gen_US
dc.contributor.authorJanus, Jen_US
dc.contributor.authorEnnis, F Aen_US
dc.date.accessioned2009-05-27T15:57:37Z
dc.date.available2009-05-27T15:57:37Z
dc.date.issued1990-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractDengue fever (DF) and dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) are major public health problems in many areas of the world. We are analyzing the human immune responses to dengue viruses, in order to understand the mechanism of recovery from dengue virus infections and the pathogenesis of DHF/DSS. Human natural killer (NK) cells lyse dengue virus-infected cells to a greater degree than uninfected cells. Antibodies to dengue viruses augment the lysis of dengue virus-infected cells by NK cells. Dengue virus-infected monocytes produce high levels of interferon alpha (IFN alpha). DR+ lymphocytes also produce high levels of IFN alpha after contact with dengue virus-infected monocytes. The IFN alpha produced protects uninfected monocytes from dengue virus infection. These results suggest that NK cells and IFN alpha may play an important role in controlling primary dengue virus infection. Dengue virus-specific CD4+CD8(-)T lymphocytes and CD4(-)CD8+T lymphocytes are present in the peripheral blood mononuclear cell population from donors who were infected with dengue virus. Most of CD4+T lymphocytes are dengue serotype-crossreactive. They lyse dengue virus-infected autologous cells in an HLA class II-restricted fashion, and produce interferon gamma (IFN gamma). IFN gamma augments dengue virus infection of monocytic cells in the presence of antidengue virus antibodies by increasing the number of Fc gamma receptors. Dengue virus-specific CD8+T lymphocytes lyse dengue virus-infected autologous cells in an HLA class I-restricted fashion. These CD8+T lymphocytes are also dengue serotype-crossreactive.(ABSTRACT TRUNCATED AT 250 WORDS)en_US
dc.description.affiliationDepartment of Medicine, University of Massachusetts Medical Center, Worcester 01655.en_US
dc.identifier.citationKurane I, Innis BL, Nimmannitya S, Nisalak A, Rothman AL, Livingston PG, Janus J, Ennis FA. Human immune responses to dengue viruses. The Southeast Asian Journal of Tropical Medicine and Public Health. 1990 Dec; 21(4): 658-62en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34079
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAntigens, Differentiation, T-Lymphocyte --immunologyen_US
dc.subject.meshCD4-Positive T-Lymphocytes --immunologyen_US
dc.subject.meshCross Reactionsen_US
dc.subject.meshDengue --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Cellular --immunologyen_US
dc.subject.meshInterferon-gamma --biosynthesisen_US
dc.subject.meshKiller Cells, Natural --immunologyen_US
dc.subject.meshSerotypingen_US
dc.subject.meshT-Lymphocytes --immunologyen_US
dc.titleHuman immune responses to dengue viruses.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
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