Atherothrombotic risk factors & premature coronary heart disease in India: A case-control study.

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dc.contributor.authorPanwar, Raja Babu
dc.contributor.authorGupta, Rajeev
dc.contributor.authorGupta, Bal Kishan
dc.contributor.authorRaja, Sadiq
dc.contributor.authorVaishnav, Jaishree
dc.contributor.authorKhatri, Meenakshi
dc.contributor.authorAgrawal, Aachu
dc.date.accessioned2011-12-07T08:14:08Z
dc.date.available2011-12-07T08:14:08Z
dc.date.issued2011-07
dc.description.abstractBackground & objectives: It was hypothesized that both thrombogenic and atherogenic factors may be responsible for premature coronary heart disease (CHD) in young Indians. A case-control study was performed to determine cardiovascular risk factors in young patients with CHD in India. Methods: Successive consenting patients <55 yr with an acute coronary event or recent diagnosis of CHD were enrolled (cases, n=165). Age- and gender-matched subjects with no clinical evidence of CHD were recruited as controls (n=199). Demographic, anthropometric, clinical, haematological, and biochemical data were obtained in both groups. Univariate and multivariate logistic regression were performed to identify important risk factors. Results: In cases vs. controls mean systolic BP, diastolic BP, platelet counts, LDL cholesterol, non-HDL cholesterol, triglycerides, and fibrinogen were higher and HDL cholesterol lower (P<0.001). The presence of current smoking, low fruit and vegetables intake, high fat intake, hypertension, diabetes, low HDL cholesterol, and high LDL cholesterol, total:HDL ratio, fibrinogen and homocysteine was significantly higher in cases (P<0.05). Multivariate logistic regression analysis (age adjusted odds ratio, 95% confidence intervals) revealed that smoking (19.41, 6.82-55.25), high fat intake (1.66, 1.08-2.56), low fruit and vegetables intake (1.99, 1.11-3.59), hypertension (8.95, 5.42-14.79), high LDL cholesterol [2.49 (1.62-3.84)], low HDL cholesterol (10.32, 6.30-16.91), high triglycerides (3.62, 2.35-5.59) high total:HDL cholesterol (3.87, 2.35-5.59), high fibrinogen (2.87, 1.81-4.55) and high homocysteine (10.54, 3.11-35.78) were significant. Interpretation & conclusions: Our results showed that thrombotic (smoking, low fruit/vegetables intake, fibrinogen, homocysteine) as well as atherosclerotic (hypertension, high fat diet, dyslipidaemia) risk factors were important in premature CHD. Multipronged prevention strategies are needed in young Indian subjects.en_US
dc.identifier.citationPanwar Raja Babu, Gupta Rajeev, Gupta Bal Kishan, Raja Sadiq, Vaishnav Jaishree, Khatri Meenakshi, Agrawal Aachu. Atherothrombotic risk factors & premature coronary heart disease in India: A case-control study. Indian Journal of Medical Research. 2011 Jul; 134(1): 26-32.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135725
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171913/en_US
dc.subjectAtherosclerosisen_US
dc.subjectcholesterolen_US
dc.subjectcoronary heart diseaseen_US
dc.subjectfibrinogenen_US
dc.subjectIndiaen_US
dc.subjectrisk factorsen_US
dc.subject.meshAdult
dc.subject.meshAtherosclerosis --epidemiology
dc.subject.meshBlood Pressure
dc.subject.meshCase-Control Studies
dc.subject.meshCholesterol, HDL --blood
dc.subject.meshCholesterol, LDL --blood
dc.subject.meshCoronary Disease --epidemiology
dc.subject.meshEating
dc.subject.meshFemale
dc.subject.meshFibrinogen --analysis
dc.subject.meshHomocysteine --blood
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPlatelet Count
dc.subject.meshRisk Factors
dc.subject.meshSmoking --adverse effects
dc.subject.meshThrombosis --epidemiology
dc.subject.meshTriglycerides --blood
dc.titleAtherothrombotic risk factors & premature coronary heart disease in India: A case-control study.en_US
dc.typeArticleen_US
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