An open clinical trial of benazepril--a new ACE inhibitor in mild-moderate hypertension.

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dc.contributor.authorKarnik, N Den_US
dc.contributor.authorOza, Y Ken_US
dc.contributor.authorSane, S Pen_US
dc.contributor.authorKaushik, Ren_US
dc.contributor.authorBhatt, A Den_US
dc.contributor.authorChawla, K Pen_US
dc.contributor.authorVaidya, A Ben_US
dc.contributor.authorYajnik, V Hen_US
dc.contributor.authorKhokhani, R Cen_US
dc.date.accessioned1998-03-29en_US
dc.date.accessioned2009-05-30T22:31:46Z
dc.date.available1998-03-29en_US
dc.date.available2009-05-30T22:31:46Z
dc.date.issued1998-03-29en_US
dc.description.abstractBenazepril hydrochloride, a new non-sulfhydryl ACE inhibitor (ACEI) was studied in a titrated dose of 10 mg-20 mg once a day for 6 weeks in 42 mild to moderate adult hypertensive patients with sitting diastolic blood pressure (SDBP) 95-114 mm Hg. The pre-drug SDBP(mean +/- SE) of 102.5 +/- 0.8 mm Hg showed a significant reduction to 87.5 +/- 0.93 mm Hg at the end of treatment. BP was controlled (SDBP < or = 90 mm Hg) in 34 (81%) patients and a drop of at least 10 mm Hg from the pre-treatment SDBP value was noted in 34 (81%) patients. Common adverse reaction was cough in 8(19%) patients. Clinically significant changes in laboratory evaluations were not seen in any patient. Study showed that benazepril in a dose range of 10 to 20 mg per day is an effective agent for treatment of mild to moderate hypertension.en_US
dc.description.affiliationLTM Medical College and Hospital, Mumbai.en_US
dc.identifier.citationKarnik ND, Oza YK, Sane SP, Kaushik R, Bhatt AD, Chawla KP, Vaidya AB, Yajnik VH, Khokhani RC. An open clinical trial of benazepril--a new ACE inhibitor in mild-moderate hypertension. Journal of the Association of Physicians of India. 1998 Mar; 46(3): 283-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/89608
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors --therapeutic useen_US
dc.subject.meshBenzazepines --therapeutic useen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleAn open clinical trial of benazepril--a new ACE inhibitor in mild-moderate hypertension.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
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