Increased number of CCR5+ CD4 T cells among south Indian adults probably associated with the low frequency of X4 phenotype of HIV-1 in India.

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dc.contributor.authorRamalingam, Sandeepen_US
dc.contributor.authorKannangai, Rajeshen_US
dc.contributor.authorVijayakumar, Theophilus Sen_US
dc.contributor.authorSubramanian, Swaminathanen_US
dc.contributor.authorAbraham, Oriapadickal Cen_US
dc.contributor.authorRupali, Priscillaen_US
dc.contributor.authorJesudason, Mary Ven_US
dc.contributor.authorSridharan, Gopalanen_US
dc.date.accessioned2002-09-07en_US
dc.date.accessioned2009-05-27T07:34:39Z
dc.date.available2002-09-07en_US
dc.date.available2009-05-27T07:34:39Z
dc.date.issued2002-09-07en_US
dc.description.abstractBACKGROUND & OBJECTIVE: The shift of the human immunodeficiency virus (HIV) from nonsyncytium inducing strains (NSI/R5) to syncytium inducing strains (SI/X4) seen in subtype B infections during progression to acquired immunodeficiency syndrome (AIDS) is less frequently reported in subtype C. NSI and SI strains differ in the co-receptor they utilize to infect a T-cell. We postulated that a larger pool of CD4 T cells expressing CCR5 would be present among individuals in the Indian population. To validate this hypothesis, we estimated the percentage of CD4 cells expressing CCR5 or CXCR4 molecules among healthy south Indian adults and HIV infected individuals. METHODS: HIV-1 infected and uninfected adult volunteers, belonging to the four southern states of India with Tamil/Malayalam/Kannada or Telugu as their spoken language were prospectively recruited. A two colour flowcytometry examination of the blood sample was done using the following monoclonals; anti-CD45 (FITC)/CD14 (PE), anti IgG1 (FITC)/IgG2a (PE), anti-CD3 (FITC)/CD4 (PE), anti-CD3 (FITC)/CD8 (PE), anti-CD4 (FITC) and anti CCR5 (PE) or anti CXCR4 (PE). RESULTS: In the healthy population (n = 30) studied, 24.6 per cent of CD4 T cells expressed CCR5 and the percentage of CD4 T cells expressing CXCR4 was 80.4. Among the HIV infected individuals (n = 51) the percentage of CD4 T cells expressing CCR5 and CXCR4 was 26.8 and 78.7 per cent respectively. INTERPRETATION & CONCLUSION: The percentage of CD4 cells expressing CCR5 and CXCR4 in both the HIV uninfected and infected adults was significantly higher in the south Indian population than in the West. The larger pool of CCR5 positive CD4 cells probably allows for the R5 HIV strain to have a replication advantage over X4 HIV strains. This may explain the lack of shift in the viral phenotype during disease progression and also the perceived rapid progression of the disease in India compared to the West.en_US
dc.description.affiliationDepartment of Clinical Virology, Christian Medical College, Vellore, India.en_US
dc.identifier.citationRamalingam S, Kannangai R, Vijayakumar TS, Subramanian S, Abraham OC, Rupali P, Jesudason MV, Sridharan G. Increased number of CCR5+ CD4 T cells among south Indian adults probably associated with the low frequency of X4 phenotype of HIV-1 in India. Indian Journal of Medical Research. 2002 Sep; 116(): 90-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/21255
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshCD4 Lymphocyte Counten_US
dc.subject.meshCD4-Positive T-Lymphocytes --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshHIV Infections --geneticsen_US
dc.subject.meshHIV-1en_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshReceptors, CCR5 --analysisen_US
dc.subject.meshReceptors, CXCR4 --analysisen_US
dc.subject.meshReference Valuesen_US
dc.titleIncreased number of CCR5+ CD4 T cells among south Indian adults probably associated with the low frequency of X4 phenotype of HIV-1 in India.en_US
dc.typeJournal Articleen_US
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