Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from India

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dc.contributor.authorChandnani, Sanjay J.en_US
dc.contributor.authorJain, Shubhamen_US
dc.contributor.authorNawghare, Pankajen_US
dc.contributor.authorDebnath, Parthaen_US
dc.contributor.authorRane, Siddheshen_US
dc.contributor.authorDeshmukh, Rahulen_US
dc.contributor.authorBansal, Saurabhen_US
dc.contributor.authorPatel, Sameeten_US
dc.contributor.authorThanage, Ravien_US
dc.contributor.authorJunare, Parmeshwaren_US
dc.contributor.authorContractor, Qaisen_US
dc.contributor.authorRathi, Pravin M.en_US
dc.contributor.authorSingh, Anupam Kumaren_US
dc.date.accessioned2023-08-19T04:52:28Z
dc.date.available2023-08-19T04:52:28Z
dc.date.issued2022-03
dc.description.abstractBackground & objectives: Coronavirus disease 2019 (COVID-19) affects respiratory, gastrointestinal, cardiovascular and other systems disease. Studies describing liver involvement and liver function test (LFT) abnormalities are sparse from our population. This study was undertaken to estimate the LFT abnormalities in patients with COVID-19 in a tertiary care set up in India. Methods: In this retrospective study conducted at a tertiary care centre in Mumbai, India, all consecutive patients with proven COVID-19 by reverse transcriptase–PCR from March 23 to October 31, 2020 were enrolled. Of the 3280 case records profiled, 1474 cases were included in the study. Clinical characteristics, biochemical parameters and outcomes were recorded. Results: Overall 681 (46%) patient had deranged LFTs. Hepatocellular type of injury was most common (93%). Patients with deranged LFTs had more probability of developing severe disease (P<0.001) and mortality (P<0.001). Advanced age (P<0.001), male gender (P<0.001), diabetes mellitus (P<0.001), lower oxygen saturation levels at admission (P<0.001), higher neutrophil–lymphocyte ratio (P<0.001), history of diabetes mellitus and cirrhosiss were associated with deranged LFTs. Acute liver injury was seen in 65 (4.3%) cases on admission and 57 (3.5%) cases during hospital stay. On multivariate analysis for predicting mortality, age >60 yr serum creatinine >2 mg%, PaO2/FiO2 ratio ?200 and raised AST >50 IU/l (OR: 2.34, CI: 1.59-3.48, P<0.001) were found to be significant. Interpretation & conclusions: In COVID-19, LFT abnormalities were common, and derangement increased as severity progressed. The presence of deranged LFT worsens the clinical outcome and predicts in-hospital mortality.en_US
dc.identifier.affiliationsDepartment of Gastroenterology, Topiwala National Medical College & Bai Yamunabai Laxmanrao Nair Charitable Hospital, Mumbai, Maharashtraen_US
dc.identifier.affiliationsDepartment of Medicine, Santosh Medical College, Ghaziabad, Uttar Pradesh, Indiaen_US
dc.identifier.citationChandnani Sanjay J., Jain Shubham, Nawghare Pankaj, Debnath Partha, Rane Siddhesh, Deshmukh Rahul, Bansal Saurabh, Patel Sameet, Thanage Ravi, Junare Parmeshwar, Contractor Qais, Rathi Pravin M., Singh Anupam Kumar. Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from India. Indian Journal of Medical Research. 2022 Sep; 156(3): 484-499en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223674
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume156en_US
dc.source.urihttps://doi.org/10.4103/ijmr.ijmr_1468_21en_US
dc.subjectCOVID-19en_US
dc.subjecthepatitisen_US
dc.subjectliver function testsen_US
dc.subjectmortalityen_US
dc.subjectrespiratory distress syndromeen_US
dc.subjectSARS-CoV-2en_US
dc.titlePattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from Indiaen_US
dc.typeJournal Articleen_US
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