Optimum management of pediatric patients with fever and neutropenia.

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dc.contributor.authorGaur, Aditya Hen_US
dc.contributor.authorFlynn, Patricia Men_US
dc.contributor.authorShenep, Jerry Len_US
dc.date.accessioned2004-09-28en_US
dc.date.accessioned2009-05-30T13:06:37Z
dc.date.available2004-09-28en_US
dc.date.available2009-05-30T13:06:37Z
dc.date.issued2004-09-28en_US
dc.description30 references.en_US
dc.description.abstractFever with neutropenia is a common clinical problem in patients receiving cancer treatment. Prevention and optimum management of infectious complications is critical to the overall success of cancer therapy. This article provides an overview of the current status of this evolving subject. While the basic principles of rapid institution of broad spectrum antibiotics, early intervention with empiric antifungal therapy and continuation of antimicrobials during period of risk are unlikely to change, there is increasing interest in titrating this aggressive approach based on the projected risk of the development of a serious invasive infection. Oral antibiotic therapy and outpatient management are currently being studied in pediatric oncology patients, but even when successful these alternatives to the traditional "in hospital, parenteral antibiotic therapy" approach are unlikely to be applicable in all patient populations and clinical settings. While there is no replacement for clinical acumen and careful monitoring, judicious use of diagnostic resources such as blood cultures and imaging studies is a key component of optimum care. Selection of empiric antibiotics based on ongoing monitoring of antimicrobial susceptibility patterns is emphasized.en_US
dc.description.affiliationDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. aditya.gaur@stjude.orgen_US
dc.identifier.citationGaur AH, Flynn PM, Shenep JL. Optimum management of pediatric patients with fever and neutropenia. Indian Journal of Pediatrics. 2004 Sep; 71(9): 825-35en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/81359
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAnti-Bacterial Agents --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshFever --diagnosisen_US
dc.subject.meshGram-Negative Bacterial Infections --complicationsen_US
dc.subject.meshGram-Positive Bacterial Infections --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshNeutropenia --diagnosisen_US
dc.titleOptimum management of pediatric patients with fever and neutropenia.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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