In-vitro anthelmintic activity of Boswellia serrata and Aloe barbadensis extracts on Pheretima posthuma: Indian earthworm

Simple item page
dc.contributor.authorShelke, Pallavi Sitaramen_US
dc.contributor.authorJagtap, Pradnya Nileshen_US
dc.contributor.authorTanpure, Prajakta Rohidasen_US
dc.date.accessioned2020-11-18T10:01:44Z
dc.date.available2020-11-18T10:01:44Z
dc.date.issued2020-05
dc.description.abstractBackground: The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in- vitro experiments were conducted to determine the possible anthelmintic effects of crude aqueous and alcoholic extracts of the resins of Boswellia serrata and leaves of Aloe barbadensis on adult Indian earthworm (Pheretima posthuma).Methods: Various concentrations (50, 100, 150 mg/ml) of each extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. The activities are well compared with the standard drug Albendazole as a positive control and saline water as negative control.Results: Anthelmintic activity was observed as dose dependent manner. It was found that alcoholic  extract exhibited maximum anthelmintic activity at concentration 100 and 150 mg/ml compared to standard drug Albendazole (10mg/ml) while aqueous extract show modest significant activity at concentration 150 mg/ml against worm Pheretima posthuma. All results was statistically analysed by using ‘Dunnett’s test’ one- way ANOVA; the p<0.001 were significant when compared with control and standard group.Conclusions: The present study proves the potential of combination of B. serrata and A. barbadensis as an anthelmintic drugs. Further studies are necessary to isolate and reveal the active compounds and to establish the mechanism of action.en_US
dc.identifier.affiliationsDepartment of Pharmacology, PDEA’s S.G.R.S. College of Pharmacy, Saswad, Maharashtra, Indiaen_US
dc.identifier.citationShelke Pallavi Sitaram, Jagtap Pradnya Nilesh, Tanpure Prajakta Rohidas. In-vitro anthelmintic activity of Boswellia serrata and Aloe barbadensis extracts on Pheretima posthuma: Indian earthworm. International Journal of Research in Medical Sciences. 2020 May; 8(5): 1843-1847en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212334
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20201939en_US
dc.subjectAnthelminticen_US
dc.subjectAloe barbadensisen_US
dc.subjectBoswellia serrataen_US
dc.subjectEarthwormen_US
dc.subjectPheretima posthumaen_US
dc.titleIn-vitro anthelmintic activity of Boswellia serrata and Aloe barbadensis extracts on Pheretima posthuma: Indian earthwormen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijrms2020v8n5p1843.pdf
Size:
550.67 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Research in Medical Sciences