HPV & HPV vaccination: Issues in developing countries.

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dc.contributor.authorBharadwaj, Mausumi
dc.contributor.authorHussain, Showket
dc.contributor.authorNasare, Vilas
dc.contributor.authorDas, Bhudev C
dc.date.accessioned2011-12-15T06:43:17Z
dc.date.available2011-12-15T06:43:17Z
dc.date.issued2009-09
dc.description.abstractCervical cancer is the second-most common cancer in women worldwide causing most cancer related deaths in women in developing countries including India. The most predominant etiological factor for cervical cancer is persistent infection of certain high-risk types of human papillomaviruses (HR-HPVs), while low-risk types are associated with benign cervical lesions and genital warts. In India, the most common (98%) oncogenic types are HPV types 16 and 18 with HPV 16 exclusively (80-90%) prevalent. Two recently developed virus-like particle (VLP) based prophylactic HPV vaccines, quadrivalent Gardasil (HPV 16/18/6/11) and Cervarix (HPV 16/18) offer great promise. Several other therapeutic vaccines are also in clinical trials and are yet to establish their efficacy. The use of already developed VLP vaccines in resource-poor regions is limited by several factors, most importantly the high cost of the vaccine. Therefore efforts are being made in India to develop cost-effective second-generation vaccines. Besides cost, there are several socio-cultural and ethical issues involved with the implementation of already developed vaccines including the acceptability of HPV vaccination by preadolescent girls and their parents in India.en_US
dc.identifier.citationBharadwaj Mausumi, Hussain Showket, Nasare Vilas, Das Bhudev C. HPV & HPV vaccination: Issues in developing countries. Indian Journal of Medical Research. 2009 Sept; 130(3): 327-333.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135900
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2009/september/0914.pdfen_US
dc.subjectCervical canceren_US
dc.subjecthuman papillomavirus (HPV)en_US
dc.subjectissues in Indiaen_US
dc.subjectprophylactic vaccinesen_US
dc.subjecttherapeutic vaccinesen_US
dc.subject.meshDeveloping Countries
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshPapillomavirus Infections --prevention & control
dc.subject.meshPapillomavirus Infections --therapy
dc.subject.meshPapillomavirus Vaccines --economics
dc.subject.meshPapillomavirus Vaccines --pharmacology
dc.subject.meshUterine Cervical Neoplasms --prevention & control
dc.subject.meshUterine Cervical Neoplasms --therapy
dc.subject.meshVaccines, DNA --pharmacology
dc.subject.meshVaccines, Synthetic --pharmacology
dc.titleHPV & HPV vaccination: Issues in developing countries.en_US
dc.typeArticleen_US
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