Association of Nonalcoholic Fatty Liver Disease with Coronary Artery Disease in Type 2 Diabetes Mellitus: A Cross‑Sectional Study from a Tertiary Care Medical College Hospital
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Date
2022-06
Journal Title
Journal ISSN
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Publisher
Wolters Kluwer - Medknow
Abstract
Introduction:Nonalcoholic fatty liver disease (NAFLD) is a risk factor for increased morbidity, mortality, and cardiovascular disease. This study was done to assess the association of NAFLD with coronary artery disease (CAD) in type 2 diabetes mellitus. Materials and Methods: The study was done as a cross‑sectional study in a tertiary care medical college hospital for 2 years among 218 adults patients of both sexes with type 2 diabetes mellitus. The study protocol was approved by the institutional ethics committee of the hospital. Age, sex, lifestyle, hypertension, personal history for smoking, and details of any previous CAD were recorded. Electrocardiogram (ECG) and ultrasonography of the abdomen were done. The association of NAFLD in type 2 diabetes mellitus patients with symptoms of angina according to modified rose and ECG changes using Minnesota codes was studied. Data collected were analyzed with Statistical Package for the Social Sciences (SPSS) version 20. Results: Of the total 218 diabetic patients, there were 92 (42.2%) were in the age group of 65–74 years. One hundred and forty‑two (65.1%) had NAFLD and 76 (34.9%) had normal liver. Eighty‑eight males and 54 female diabetic patients had NAFLD. Of the NAFLD patients 88 (58%) were smokers, 77 (54%) were obese, and 72 (51%) had hypertension. Low‑density lipoprotein was increased in 132 (93%) patients with NAFLD. Angina symptoms according to modified rose questionnaire was present in 26 (18%) of NAFLD patients. Probable ST/T and Q/QS ECG changes according to Minnesota coding was present in 32 (22.53%) and in 26 (18.3%) of diabetic patients with NAFLD. Conclusion: There is significant association of coronary artery disease and cardiovascular risk factors with NAFLD in type 2 diabetes.
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Keywords
Cardiovascular risk factors, coronary artery disease, diabetes, nonalcoholic fatty liver disease
Citation
Ramya Neelakandan, Karthikeya Golepu, Shankar Sethu Prabhu . Association of Nonalcoholic Fatty Liver Disease with Coronary Artery Disease in Type 2 Diabetes Mellitus: A Cross‑Sectional Study from a Tertiary Care Medical College Hospital. Acta Medica International. 2022 Jun; 9(1): 31-35