Clinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy.

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dc.contributor.authorPadma, M Ven_US
dc.contributor.authorSimkins, Roberten_US
dc.contributor.authorWhite, Phillipen_US
dc.contributor.authorSatter, Martinen_US
dc.contributor.authorChristian, Brad Ten_US
dc.contributor.authorDunigan, Kellyen_US
dc.contributor.authorLee, Candien_US
dc.contributor.authorJacobs, Men_US
dc.contributor.authorMukherjee, Jen_US
dc.contributor.authorMantil, Joseph Cen_US
dc.date.accessioned2004-12-01en_US
dc.date.accessioned2009-06-03T12:25:31Z
dc.date.available2004-12-01en_US
dc.date.available2009-06-03T12:25:31Z
dc.date.issued2004-12-01en_US
dc.description.abstractBACKGROUND: 11C-flumazenil (FMZ) positron emission tomography (PET) is a new entrant into the armamentarium for pre-surgical evaluation of patients with intractable temporal lobe epilepsy (TLE). AIMS: To analyze the clinical utility of FMZ PET to detect lesional and remote cortical areas of abnormal benzodiazepine receptor binding in relation to magnetic resonance imaging (MRI), 2-Deoxy-2 [18F] fluoro-D-glucose, (18F FDG) PET, electrophysiological findings and semiology of epilepsy in patients with intractable TLE. MATERIALS AND METHODS: Patients underwent a high resolution MRI, prolonged Video-EEG monitoring before 18F FDG and 11C FMZ PET studies. Regional cortical FMZ PET abnormalities were defined on co-registered PET images using an objective method based on definition of areas of abnormal asymmetry (asymmetry index {AI}>10%). SETTINGS AND DESIGN: Prospective. STATISTICAL ANALYSIS: Student's "t" test. RESULTS: Twenty patients (Mean age: 35.2 years [20-51]; M:F=12:8) completed the study. Mean age at seizure onset was 10.3 years (birth-38 years); mean duration, 23.9 years (6-50 years). Concordance with the MRI lesion was seen in 10 patients (nine with hippocampal sclerosis and one with tuberous sclerosis). In the other 10, with either normal or ambiguous MRI findings, FMZ and FDG uptake were abnormal in all, concordant with the electrophysiological localization of the epileptic foci. Remote FMZ PET abnormalities (n=18) were associated with early age of seizure onset (P=0.005) and long duration of epilepsy (P=0.01). CONCLUSIONS: FMZ-binding asymmetry is a sensitive method to detect regions of epileptic foci in patients with intractable TLE.en_US
dc.description.affiliationDepartment of Nuclear Medicine, Kettering Medical Center, Wright State University, Kettering, Ohio 45429, USA. vasanthapadma123@rediffmail.comen_US
dc.identifier.citationPadma MV, Simkins R, White P, Satter M, Christian BT, Dunigan K, Lee C, Jacobs M, Mukherjee J, Mantil JC. Clinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy. Neurology India. 2004 Dec; 52(4): 457-62en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121545
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdulten_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshEpilepsy, Temporal Lobe --radionuclide imagingen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlumazenil --diagnostic useen_US
dc.subject.meshFluorodeoxyglucose F18 --diagnostic useen_US
dc.subject.meshFunctional Lateralityen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPositron-Emission Tomographyen_US
dc.subject.meshRadiopharmaceuticals --diagnostic useen_US
dc.titleClinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy.en_US
dc.typeJournal Articleen_US
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