Low dose cyclosporine-a therapy in severe aplastic anaemia.

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dc.contributor.authorRai, Men_US
dc.contributor.authorSingh, V Pen_US
dc.contributor.authorShukla, Jen_US
dc.contributor.authorSundar, Sen_US
dc.contributor.authorJha, V Cen_US
dc.date.accessioned2001-10-19en_US
dc.date.accessioned2009-05-30T20:04:23Z
dc.date.available2001-10-19en_US
dc.date.available2009-05-30T20:04:23Z
dc.date.issued2001-10-19en_US
dc.description.abstractOBJECTIVE: The present study was conducted to evaluate the efficacy of low dose cyclosporine-A in the patients of severe aplastic anaemia, who cannot afford allogenic bone marrow transplantation and immunosuppressive therapy with antithymocyte globulin. METHODS: The diagnosis of severe aplastic anaemia was established by standard criteria. Twelve patients were given cyclosporine-A orally at a dose of 6 mg/kg body weight in divided doses in two daily equal proportions for six months. Eleven patients were put on oral stanozolol in the dosage of 1 mg/kg body weight/day in divided doses. All surviving patients were evaluated at three and six months. RESULTS: At the end of six months, 41.66% of twelve patients responded to cyclosporine-A. One patient had complete response and four patients had partial response. Only one out of 11 patients receiving stanozolol responded. CONCLUSIONS: i) Cyclosporine-A is a viable therapeutic option in the treatment of severe aplastic anaemia, ii) Low dose cyclosporine-A is able to slow down the stormy course of the severe aplastic anaemia, iii) Androgens have very little effect on the survival of patients of severe aplastic anaemia.en_US
dc.description.affiliationDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi.en_US
dc.identifier.citationRai M, Singh VP, Shukla J, Sundar S, Jha VC. Low dose cyclosporine-a therapy in severe aplastic anaemia. Journal of the Association of Physicians of India. 2001 Oct; 49(): 966-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/87363
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshAnabolic Agents --administration & dosageen_US
dc.subject.meshAnemia, Aplastic --drug therapyen_US
dc.subject.meshChilden_US
dc.subject.meshCyclosporine --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshStanozolol --administration & dosageen_US
dc.subject.meshTime Factorsen_US
dc.titleLow dose cyclosporine-a therapy in severe aplastic anaemia.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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