A comparative study in the outcome between the two fixed doses of polyvalent anti snake venom, 10 vials versus 20 vials, with mechanical ventilation in children with severe neurotoxic snake envenomation

Simple item page
dc.contributor.authorV., Shekaren_US
dc.contributor.authorSoren, Chapayen_US
dc.contributor.authorReddy, K. Venkataramanaen_US
dc.contributor.authorV. V., Lakshmi Aparnadevien_US
dc.contributor.authorKumar, Saien_US
dc.date.accessioned2020-09-24T07:48:36Z
dc.date.available2020-09-24T07:48:36Z
dc.date.issued2020-07
dc.description.abstractBackground: Every year about 50,000, people die of snake bites in India. Anti-snake venom and mechanical ventilation is mainstay of treatment in cases with severe neurotoxic envenomation. ASV is costly and scarce resource. There is lack of universal consensus towards the optimal dose of ASV in management protocol for children with severe neurotoxic snake envenomation. Objective was to compare the difference in outcome between two fixed doses of ASV, 10vials versus 20 vials, in children with severe neurotoxic snake envenomationMethods: This comparative observational study was carried out for a period of 3 years in Department of Pediatrics of SVS Medical College, Mahabubnagar, Telangana, India. Children with history of snake bite and clinical evidence of neuroparalysis were included. In addition to the mechanical ventilation and other supportive measures, every alternate patient was administered with 10vials (low dose) and 20 vials (high dose) of ASV over 1 hour. Outcome was compared between the two groups.Results: Of the 62 patients, 32 were in each group. The median time to extubation was 41 hours and 39.5 hours and mean duration of the hospital stay was 4.6 days and 4.5 days among the low dose and high dose groups, respectively. There were three deaths, one from low dose group and two from high dose group.Conclusions: There was no significant difference in outcome between the 10 vials vs 20 vials of ASV in addition to mechanical ventilation in treatment of children with severe neurotoxic snake envenomation. So, 10 vials of ASV can be utilized to reduce the cost of treatment.en_US
dc.identifier.affiliationsDepartment of Pediatrics, PGIMS, Rohtak, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, BPS, Khanpur, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Surgery, PGIMS, Rohtak, Haryana, Indiaen_US
dc.identifier.citationV. Shekar, Soren Chapay, Reddy K. Venkataramana, V. V. Lakshmi Aparnadevi, Kumar Sai. A comparative study in the outcome between the two fixed doses of polyvalent anti snake venom, 10 vials versus 20 vials, with mechanical ventilation in children with severe neurotoxic snake envenomation. International Journal of Contemporary Pediatrics. 2020 Jul; 7(7): 1540-1543en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204674
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber7en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20202612en_US
dc.subjectAnti-snake venomen_US
dc.subjectMechanical ventilationen_US
dc.subjectNeuroparalysisen_US
dc.subjectSnake biteen_US
dc.titleA comparative study in the outcome between the two fixed doses of polyvalent anti snake venom, 10 vials versus 20 vials, with mechanical ventilation in children with severe neurotoxic snake envenomationen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijcp2020v7n7p1540.pdf
Size:
350.35 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Contemporary Pediatrics