Role of phosphatase and tensin homolog in pathogenesis of ameloblastoma: An immunohistochemical study

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dc.contributor.authorNarayan, Bhaskaren_US
dc.contributor.authorUrs, Aadithya Ben_US
dc.contributor.authorAugustine, Jeyaseelanen_US
dc.contributor.authorSingh, Hanspalen_US
dc.date.accessioned2020-11-18T10:08:21Z
dc.date.available2020-11-18T10:08:21Z
dc.date.issued2020-07
dc.description.abstractBackground: Altered molecular signaling pathways in ameloblastoma have been identified to play a pivotal role in the mechanism of oncogenesis, differentiation, and tumor progression. Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway is one of the signaling pathways that are associated with the pathogenesis of ameloblastoma. Phosphatase and tensin homolog (PTEN) controls cell migration and proliferation. It monitors the level of the Akt and maintains cellular integrity. The present study was aimed to study the immunoexpression of PTEN in ameloblastoma to understand its role in the pathogenesis of ameloblastoma. Materials and Methods: Twenty cases of ameloblastoma and ten cases of normal tooth germ were subjected to immunohistochemical staining against PTEN. Results: Strong PTEN immunopositivity was seen in the tooth germs, while weak positivity was seen in the ameloblastoma. The immunoscore for PTEN was calculated by adding the percentage score and the intensity score. Seventeen cases showed the reduced PTEN expression in the epithelial component of ameloblastoma. The unpaired t-test showed a statistically significant difference in the mean PTEN immunoscore in tooth germ and ameloblastoma. Conclusion: The study showed reduced PTEN immunoreactivity, which plays a role in the pathogenesis of ameloblastoma, through Akt pathwayen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Maulana Azad Institute of Dental Sciences, New Delhi, Indiaen_US
dc.identifier.citationNarayan Bhaskar, Urs Aadithya B, Augustine Jeyaseelan, Singh Hanspal. Role of phosphatase and tensin homolog in pathogenesis of ameloblastoma: An immunohistochemical study. Journal of Cancer Research and Therapeutics. 2020 Jul; 16(3): 513-516en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213850
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_528_18en_US
dc.subjectAmeloblastomaen_US
dc.subjectimmunohistochemistryen_US
dc.subjectphosphatase and tensin homologen_US
dc.subjecttooth germsen_US
dc.titleRole of phosphatase and tensin homolog in pathogenesis of ameloblastoma: An immunohistochemical studyen_US
dc.typeJournal Articleen_US
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