Dexamethasone therapy for bacterial meningitis in adults: a double blind placebo control study.

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dc.contributor.authorGijwani, Den_US
dc.contributor.authorKumhar, M Ren_US
dc.contributor.authorSingh, V Ben_US
dc.contributor.authorChadda, V Sen_US
dc.contributor.authorSoni, P Ken_US
dc.contributor.authorNayak, K Cen_US
dc.contributor.authorGupta, B Ken_US
dc.date.accessioned2002-03-18en_US
dc.date.accessioned2009-06-03T11:50:06Z
dc.date.available2002-03-18en_US
dc.date.available2009-06-03T11:50:06Z
dc.date.issued2002-03-18en_US
dc.description.abstractRoutine use of steroids in the treatment of bacterial meningitis remains controversial. A prospective placebo controlled double blind study of dexamethasone was carried out in 40 patients (age>10 years) of acute bacterial meningitis. The patients were randomly assigned to receive either placebo (n=20) or dexamethasone (n=20) in addition to injection ceftriaxone 100 mg/kg/day (maximum 4 gm/day) for 14 days. Dexamethasone sodium phosphate was given in dose of 0.6 mg/kg/day in 4 divided doses, for first 4 days of therapy. First dose of dexamethasone was given 15 minutes prior to first dose of ceftriaxone. Baseline demographics, clinical and laboratory features of the two groups were similar. Clinical improvement of signs of meningeal irritation was rapid in dexamethasone group than in the placebo group, but no significant difference was observed regarding resolution of fever, headache and vomiting. Secondary fever (mean+/-SD 15.00), gastrointestinal tract bleeding (mean+/-SD 15.00) and psychiatric manifestations (mean+/-SD 10.00) were more common in dexamethasone group. Neurological complications and hearing loss were more common and severe in placebo group as compared to the dexamethasone group (p<0.05). It is concluded that dexamethasone may be beneficial in some aspects of bacterial meningitis, in adults. A study with a larger number of cases in each group is recommended.en_US
dc.description.affiliationDepartment of Medicine, S.P. Medical College, Bikaner, Rajasthan, 334003, India.en_US
dc.identifier.citationGijwani D, Kumhar MR, Singh VB, Chadda VS, Soni PK, Nayak KC, Gupta BK. Dexamethasone therapy for bacterial meningitis in adults: a double blind placebo control study. Neurology India. 2002 Mar; 50(1): 63-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121152
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Inflammatory Agents --therapeutic useen_US
dc.subject.meshCefuroxime --therapeutic useen_US
dc.subject.meshCephalosporins --therapeutic useen_US
dc.subject.meshDexamethasone --therapeutic useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMeningitis, Bacterial --drug therapyen_US
dc.subject.meshPlacebosen_US
dc.titleDexamethasone therapy for bacterial meningitis in adults: a double blind placebo control study.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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