Design
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Date
2019-12
Journal Title
Journal ISSN
Volume Title
Publisher
Bimonthly published online Journal
Abstract
According to one pot microwave assisted synthesis, the versatile precursor 2- aminothiazole was prepared and utilized for the construction of new thiazole hybrids targeting MCF7 cell lines. 2‐amino thiazole was condensed with corresponding aldehydes to yield Schiff’sbase (2) intermediates followed by the diazo coupling reaction furnished the designed hybrids(3) contains azo-methine and diazo linkages in its structures. The newly synthesizedcompounds were confirmed on the basis of IR and H1NMR spectral analytical data. All thesynthesized compounds were evaluated for their in-vitro cytotoxicity activity against MCF-7celllines using MTT assay method. The obtained results revealed the more promising compoundsof the synthesised series, 3B and 3H with CTC50 value of 17.77±0.31μg/ml, 17.83±1.14 μg/ml.
Description
Keywords
Thiazole, schiff’s base, Azo compounds, Cytotoxicity, MCF-7, MTT assay.
Citation
Umakrithika S, Chandraleka K, Fahima S, Karthika S, Geetha B. Design
Synthesis
Characterization And In-Vitro Anticancer Studies Of Novel Substituted Azo Linked Schiff Base Hybrids. International Journal of Pharmaceutical Research and Bioscience (IJPRBS). 2019 Dec; 8(6): 12-22
Synthesis
Characterization And In-Vitro Anticancer Studies Of Novel Substituted Azo Linked Schiff Base Hybrids. International Journal of Pharmaceutical Research and Bioscience (IJPRBS). 2019 Dec; 8(6): 12-22