A new indication of sildenafil in medicine: hypoxic cell sensitizer for penile cancer.

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dc.contributor.authorHuilgol, Nagraj Gen_US
dc.contributor.authorJain, Amiten_US
dc.date.accessioned2006-07-14en_US
dc.date.accessioned2009-06-01T16:14:01Z
dc.date.available2006-07-14en_US
dc.date.available2009-06-01T16:14:01Z
dc.date.issued2006-07-14en_US
dc.description.abstractPURPOSE: To evaluate the feasibility and results of sildenafil used as radiosensitizer by causing penile vasodilatation and reducing tumor hypoxia in radical radiotherapy for penile cancer. MATERIALS AND METHODS: Three men with histopathologic diagnosis of squamous carcinoma of penis were treated with radical external radiotherapy with concomitant sildenafil. Acute and late adverse events were noted according to RTOG toxicity criteria. Response to radiotherapy, as well as disease-free and overall survivals, was evaluated. RESULTS: All three patients achieved tumescence, completed the treatment and achieved complete response. One patient had recurrence at 10 months and died of the disease after 23 months from starting the treatment. Other two patients are disease-free and alive at 48 and 53 months respectively. No excess acute or late adverse event was observed. CONCLUSION: Sildenafil may act as radiosensitizer by causing penile vasodilatation and reducing hypoxia. Larger controlled studies are required to validate the hypothesis.en_US
dc.description.affiliationDepartment of Radiation Oncology, Nanavati Hospital, Mumbai, India. nagrajh@vsnl.neten_US
dc.identifier.citationHuilgol NG, Jain A. A new indication of sildenafil in medicine: hypoxic cell sensitizer for penile cancer. Journal of Cancer Research and Therapeutics. 2006 Jul-Sep; 2(3): 132-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111403
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshAdulten_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshCarcinoma --drug therapyen_US
dc.subject.meshCell Hypoxia --drug effectsen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPenile Neoplasms --drug therapyen_US
dc.subject.meshPhosphodiesterase Inhibitors --therapeutic useen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPiperazines --therapeutic useen_US
dc.subject.meshPurines --therapeutic useen_US
dc.subject.meshSulfones --therapeutic useen_US
dc.titleA new indication of sildenafil in medicine: hypoxic cell sensitizer for penile cancer.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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