Cherubism - A case report with long term follow up.

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dc.contributor.authorChavali, Lakshmi V
dc.contributor.authorBhimalingam, R M Rao
dc.contributor.authorSudhakar, P V
dc.date.accessioned2012-10-15T04:39:05Z
dc.date.available2012-10-15T04:39:05Z
dc.date.issued2011-10
dc.description.abstractCherubism is a rare non-neoplastic disease of the bone characterized by bilateral painless enlargement of the jaws giving a cherubic appearance to the patient. It is an autosomal dominant disorder but may occur sporadically. In this paper, we have tried to explain about the clinical, radiological and histopathologic features of cherubism by presenting a case study. A case study of a 7 year old male patient, who first presented with mandibular bilateral swellings to our department in 1998, has been presented. In-depth clinical, radiological and histopathologic examination was done. An extensive long-term follow-up till 11 years was maintained. When presented for the first time, radiological investigation showed characteristic multilocular lytic lesions of the mandible bilaterally. Histopathological examination of the biopsy specimen showed proliferating fibrous connective tissue interspersed by multinucleated giant cells. It was diagnosed as a case nonfamilial cherubism. Follow-up after 5 years showed involvement of the maxilla as well, which was then corrected by surgical methods. Upon follow up 11 years after the first presentation, it was seen that the lesion was regressing by itself and there was improvement in facial contour. The natural course of Cherubism through its progression, stabilization and involution of the disease after puberty, has been highlighted in this case. More, in-depth studies to understand the nature and the pathogenesis of this condition better are required.en_US
dc.identifier.citationChavali Lakshmi V, Bhimalingam R M Rao, Sudhakar P V. Cherubism - A case report with long term follow up. Indian Journal of Pathology & Microbiology. 2011 Oct-Dec 54(4): 793-795.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142114
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=4;spage=793;epage=795;aulast=Chavalien_US
dc.subjectCherubismen_US
dc.subjectdiagnosisen_US
dc.subjectpathologyen_US
dc.subject.meshBiopsy
dc.subject.meshCherubism --diagnosis
dc.subject.meshCherubism --pathology
dc.subject.meshChild
dc.subject.meshFollow-Up Studies
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshJaw --pathology
dc.subject.meshJaw --radiography
dc.subject.meshMale
dc.subject.meshMaxilla --pathology
dc.subject.meshMaxilla --radiography
dc.subject.meshMicroscopy
dc.subject.meshTomography, X-Ray Computed
dc.titleCherubism - A case report with long term follow up.en_US
dc.typeArticleen_US
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