Liver histology in patients on hemodialysis with chronic hepatitis C viral infection.

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dc.contributor.authorMysorekar, Vijaya Ven_US
dc.contributor.authorRao, Saraswathi Gen_US
dc.contributor.authorMahadeva, K Cen_US
dc.date.accessioned2008-04-08en_US
dc.date.accessioned2009-05-29T13:06:22Z
dc.date.available2008-04-08en_US
dc.date.available2009-05-29T13:06:22Z
dc.date.issued2008-04-08en_US
dc.description.abstractHepatitis C virus (HCV) is a major cause of chronic liver disease in patients on hemodialysis. As no useful noninvasive predictors of disease activity and fibrosis have been found, liver biopsy is essential in these patients to accurately assess the severity of disease and thus the prognosis and plan management. The present study was undertaken to assess the degree of severity of necroinflammatory changes and fibrosis in liver biopsies of patients on hemodialysis with chronic HCV infection. Liver biopsies obtained from 45 patients on hemodialysis with serological evidence of chronic hepatitis C were studied. The grading of necroinflammatory activity and staging of fibrosis were histologically assessed. The majority of patients (30, i.e. 66.7%) had mild disease with mild inflammatory activity and stage 0, 1 or 2 fibrosis. There was no significant correlation between the degree of fibrosis and the age of the patients (rs = 0.015), the duration of hemodialysis (rs = 0.047) or the presence of steatosis (rs = 0.064). There was a positive correlation between the presence of bile ductular proliferation and the severity of fibrosis (rs = 0.612). It was concluded that chronic HCV infection in hemodialysis patients is relatively mild early in its course. However, serial follow-up liver biopsies are mandatory to plan appropriate intervention strategies.en_US
dc.description.affiliationDepartment of Pathology, M.S. Ramaiah Medical College, Bangalore, Karnataka, India. vijayamysorekar@yahoo.comen_US
dc.identifier.citationMysorekar VV, Rao SG, Mahadeva KC. Liver histology in patients on hemodialysis with chronic hepatitis C viral infection. Indian Journal of Pathology & Microbiology. 2008 Apr-Jun; 51(2): 182-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75298
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBile Ducts --pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrosisen_US
dc.subject.meshHepatitis C, Chronic --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRenal Dialysisen_US
dc.titleLiver histology in patients on hemodialysis with chronic hepatitis C viral infection.en_US
dc.typeJournal Articleen_US
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