Correlations between maximum standardized uptake value measured via 18F-fluorodeoxyglucose positron emission tomography/computed tomography and clinical variables and biochemical indicators in adult lymphoma

Simple item page
dc.contributor.authorLi, Honglingen_US
dc.contributor.authorWang, Xiaohuanen_US
dc.contributor.authorZhang, Lingfangen_US
dc.contributor.authorYi, Xuemeien_US
dc.contributor.authorQiao, Yujieen_US
dc.contributor.authorJin, Qianqianen_US
dc.date.accessioned2020-11-18T10:07:33Z
dc.date.available2020-11-18T10:07:33Z
dc.date.issued2020-01
dc.description.abstractObjectives: The aim of the current study was to investigate whether the maximum standardized uptake value (SUVmax) measured by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) could discriminate between aggressive and indolent non-Hodgkin lymphomas (NHLs) and correlations between the SUVmax and clinical variables and serum biochemical indicators in adult lymphoma. Methods: A total of 103 patients with lymphoma confirmed by biopsy, pretreatment 18F-FDG PET/CT scans, and a complete medical record were retrospectively enrolled in the study. Clinical variables that were evaluated included stage, pathological subtype, International Prognostic Index (IPI) score, and Ki-67 index, as well as serum biochemical indicators (e.g., lactate dehydrogenase [LDH] and erythrocyte sedimentation rate [ESR]) and metabolic parameters (e.g., SUVmax of the biopsy site on PET/CT). Correlations between SUVmax and clinical variables and serum biochemical indicators were investigated. Results: Of the 103 patients, 84 had NHL and 19 had Hodgkin lymphoma. The area under the receiver operating characteristic curve for examining the accuracy of SUVmax with regard to distinguishing between aggressive and indolent NHLs was 0.94 (95% confidence interval: 0.89–0.99), suggesting that SUVmax was a useful predictor of diagnosis. A cutoff value of 8.5 yielded a sensitivity of 76.3% and specificity of 92.0%. The SUVmax mean ± standard deviation of NHL (9.8 ± 6.0, range: 1.8–28.1) was higher than that of HL (7.5 ± 2.8, range: 3.5–13.9) (P = 0.016), but there was no statistically significant difference in SUVmax between NHL and HL (P > 0.05). SUVmax of the biopsy site was strongly positively correlated with Ki-67 index (r = 0.813, P < 0.001) and moderately positively correlated with IPI score (r = 0.332, P = 0.002), but it was not significantly correlated with clinical stage, LDH, or ESR (P > 0.05). Conclusions: 18F-FDG PET/CT may yield reliable measurements of tumor proliferation, and an SUVmax >8.5 may distinguish between aggressive and indolent NHLs. In adults with newly diagnosed lymphoma, SUVmax correlates with Ki-67 index and IPI scoreen_US
dc.identifier.affiliationsLanzhou University; Department of Oncology, Gansu Provincial Hospital, Lanzhou, Gansu, Chinaen_US
dc.identifier.affiliationsDepartment of Oncology, Gansu Provincial Hospital, Lanzhou, Gansu, Chinaen_US
dc.identifier.affiliationsDepartment of Oncology, Gansu Provincial Hospital, Lanzhou, Gansu, Chinaen_US
dc.identifier.affiliationsDepartment of Oncology, Gansu Provincial Hospital, Lanzhou, Gansu, Chinaen_US
dc.identifier.affiliationsDepartment of Oncology, Gansu Provincial Hospital, Lanzhou, Gansu, Chinaen_US
dc.identifier.affiliationsDepartment of Oncology, Gansu Provincial Hospital, Lanzhou, Gansu, Chinaen_US
dc.identifier.citationLi Hongling, Wang Xiaohuan, Zhang Lingfang, Yi Xuemei, Qiao Yujie, Jin Qianqian. Correlations between maximum standardized uptake value measured via 18F-fluorodeoxyglucose positron emission tomography/computed tomography and clinical variables and biochemical indicators in adult lymphoma. Journal of Cancer Research and Therapeutics. 2020 Jan; 15(6): 1581-1588en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213574
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber6en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_671_18en_US
dc.subject18F-fluorodeoxyglucoseen_US
dc.subjectKi-67en_US
dc.subjectlymphomaen_US
dc.subjectpositron emission tomography/computed tomographyen_US
dc.subjectstandardized uptake valueen_US
dc.titleCorrelations between maximum standardized uptake value measured via 18F-fluorodeoxyglucose positron emission tomography/computed tomography and clinical variables and biochemical indicators in adult lymphomaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ijcrt2019v15n7p1581.pdf
Size:
1.44 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Cancer Research and Therapeutics